术前应用氟比洛芬酯与阿扎司琼对小儿斜视矫正术术后疼痛及呕吐的影响

Objective To study the effect of preoperative flurbiprofen axetil combined with azasetron on postoperative pain and nausea and vomiting in children undergoing strabismus surgery. Methods A total of 60 children, ASA Ⅰ -Ⅱ, aged 8-14, scheduled for strabismus surgery with total intravenous general anesthesia were randomly assigned to 3 groups(n=20). In group FA, flurbiprofen axetil(1mg/kg)combined with azasetron(0.2mg/kg)was intravenously injected; only flurbiprofen axetil(1mg/kg)was give in group F and only azasetron(0.2mg/kg)was injected in group A. The above drugs were all administered 10 min before the anesthetic induction. VAS scores and glucose at the end of surgery and after surgery were recorded individually.The incidence rate of restless, nausea and vomiting after surgery were recorded. Results The incidence rate of pain in group FA and group F were significantly lower than that in group A(P <0.05). The postoperative glucose in group A were significantly higher than that in group FA and group F(P <0.05). The incidence rate of nausea and vomiting in group FA and group A were significantly lower compared with group F(P <0.05).Conclusions Flurbiprofen axetil combined with Azasetron can reduce the adverse reactions, such as pain,nausea and vomiting in children undergoing strabismus surgery.

Effect of preoperative administration of flurbiprofen axetil combined with azasetron on postoperative pain and nausea and vomiting in children undergoing strabismus surgery