不同手术方式对子宫切除术患者细胞免疫功能的影响

目的 比较不同手术方式对子宫切除术患者细胞免疫功能的影响.方法 57例子宫切除术患者,根据手术方式的不同被分为开腹手术组(n=30)及腹腔镜手术组(n=27).所有患者于术前及术后1、3 d监测T细胞亚群CD3+、CD4+、CD4+/CD8+的变化.结果 与术前比较,两组术后1 d CD3+、CD4+显著降低(P<0.05),CD4+/CD8+比值降低(P<0.01),术后3 d均恢复至正常水平.腹腔镜组术后1 d的CD3+、CD4+、CD4+/CD8+比值降低幅度均明显低于开腹手术组(P<0.05或P<0.01).结论 腹腔镜手术较传统剖腹手术对妇科手术患者的细胞免疫功能抑制程度较轻.

Change of cellular immune function in patients with uterine myomas proceeding different operation way

Objective To observe the change of cellular immune function in patients with uterine myomas proceeding laparoscope or abdomen operation. Methods 57 patients with uterine myomas were divided into two groups: laparoscope group (LA, n=27) and operation group (OA, n=30). CD3+, CD4+ and CD4+/CD8+in vein were determined before operation and 1,3 d after operation. Results Compared with that before operation, CD3+ and CD4+ at 1 d after operation in both two groups decreased markedly(P<0.05), and CD4+/CD8+decreased markedly(P<0.01). all index at 3 d after operation returned to nomal level. the decreasive degree of CD3+, CD4+, CD4+/CD8+ in LA group was lower than that in OA group(P<0.05 or P<0.01). Conclusion Different operation way including operation abdomen or laparoscopic uterinectomy can suppress cellular immune function, but the effect of laparoscope was smaller than that using abdomen operation.