他克莫司乳膏联合308nm高能准分子光治疗外阴白癜风30例临床疗效观察

目的：观察他克莫司乳膏联合308nm高能准分子光治疗外阴白癜风的临床疗效。方法：外阴白癜风患者60例,随机分为试验组和对照组,每组30例。试验组皮损区每天外用0.1%他克莫司乳膏2次,再给予每周2次308nm高能准分子光治疗;对照组仅给予每周2次308nm高能准分子光治疗,3个月后评价临床疗效。结果：两组有效率分别为90.0%、66.7%,差异有显著统计学意义（χ^2=4.81,P〈0.01）。结论：他克莫司软膏联合308nm高能准分子光治疗外阴白癜风可以促进皮损色素再生和扩散,是一种安全、高效的方法。

Efficacy of Tarcrolimus cream combined with 308 nm high-energy excimer laser in the treatment of genital vitiligo

Objectives： To observe the clinical efficacy of tarcrolimus cream combined with 308 nm high-energy excimer laser in the treatment of genital vitiligo. Method： 60 patients were randomly divided into experimental group and control group,with 30 cases in each group. For experimental group： use 0. 1% tarcrolimus cream twice a day combined with 308 nm high- energy excimer laser twice a week. For control group： use 308 nm high-energy excimer laser only twice a week. Evaluate the clinical efficacy of the 2 groups 3 months later. Results： The effective rate of experimental group and control group was 90. 0% and 66. 7% respectively; the difference was of statistical significance（ χ^2= 4. 81,P〈0. 01）. Conclusion： To treat genital vitiligo,the combination therapy of tarcrolimus cream and 308 nm high- energy excimer laser can promote skin pigment regeneration and diffusion. The treatment is safe and efficient.