复方甲硝唑栓联合倍美力软膏治疗老年性阴道炎的临床研究

目的：探讨复方甲硝唑栓联合倍美力软膏治疗老年性阴道炎的临床疗效和安全性。方法：选取2011年1月至2012年12月来本院妇科就诊的老年性阴道炎患者共130例作为研究对象。根据入院时间将患者随机分为观察组和对照组,每组各65人。对照组采用甲硝唑栓进行治疗,观察组加用倍美力软膏进行联合治疗。对比两组临床表现改善情况、血清激素水平和临床疗效。结果：治疗后,与对照组相比,观察组白带增多、阴道瘙痒和阴道壁红肿充血症状明显缓解（χ^2=4.33、4.01、6.39,P均〈0.05）;治疗后,与对照组相比,观察组血清FSH水平升高幅度较大（U=8.43,P〈0.05）,E2降低幅度较大（U=5.59,P〈0.05）;观察组治愈率和总有效率分别为63.08%和95.38%,均高于对照组（44.62%,81.54%）（χ^2=4.46、6.10,P均〈0.05）。结论：复方甲硝唑栓联合倍美力软膏治疗老年性阴道炎较单纯应用复方甲硝唑栓具有明显的优势,给药方便,安全可靠,值得在临床上进一步推广。

Effect of compound metronidazole suppositories and premarin ointment on the treatment of senile vaginitis

Objectives： To investigate the clinical efficacy and safety of compound metronidazole suppositories and premarin ointment for the treatment of senile vaginitis. Methods： 130 patients with senile vaginitis having received treatment in the Department of Gynecology of our hospital from January 2011 to December 2012 were selected as research objects,and randomly divided into observation group and control group according to the admissiontime,each of 65 patients. Patients in the control group were treated with compound metronidazole suppositories while patients in the observation group received the joint treatment of compound metronidazole suppositories and premarin ointment. The clinical improvement,serum hormone levels and clinical curative effect of the 2 groups were compared. Results： After treatment,compared with the control group,the leukorrhagia,vaginal itching and swelling congestion symptoms of vaginal wall in the observation group were obviously alleviated（ χ^2= 4. 33,4. 01,4. 33, P〈0. 05）; after treatment,compared with the control group,the increase of serum FSH level（ U = 8. 43,P 〈0. 05） and the decrease of E2（ U = 5. 59,P〈0. 05） in the observation group were much larger; the cure rate and total effective rate of the observation group were 63. 08% and 95. 38% respectively,higher than the control group（ 44. 62%,81. 54%）（ χ^2= 4. 46,4. 46,P 0. 05）. Conclusion： Compared with using compound metronidazole suppositories alone,the joint use of compound metronidazole suppositories and premarin ointment is of obvious advantages,convenient,safe and reliable,and worthy of further promotion.