急性冠脉综合症患者测定hsCRP、Nt—proBNP的临床意义

目的探讨联合检测氨基末端脑钠肽前体和高敏C反应蛋白（hsCRP）在急性冠状动脉综合征中的临床价值。方法将急性冠状动脉综合征（ACS）患者106例，分为不稳定型心绞痛组（UAP组）36例，急性非ST段抬高性心肌梗死组（NSTEMI组）37例与急性ST段抬高性心肌梗死组（STEMI组）33例；同期正常体检者30例作为对照组，分别检测血清氨基末端脑钠肽前体和高敏C反应蛋白水平，并进行比较。结果ACS组血清氨基末端脑钠肽前体与高敏C反应蛋白水平显著高于对照组（P〈0．05）；NSTEMI组氨基末端脑钠肽前体水平高于UAP组（P〈0．05）；STEMI组氨基末端脑钠肽前体、高敏C反应蛋白水平高于NSTEMI组和UAP组（P〈0．05）；NSTEMI组与UAP组高敏C反应蛋白水平比较差异有统计学意义（P〉0．05）。结论联合检测氨基末端脑钠肽前体和高敏C反应蛋白水平可判断急性冠状动脉综合征的严重程度，对其诊治及预后评价均有重要参考价值。

Clinical Significance of High Sensitivity C-Reactive Protein and NT-ProBNP in Acute Coronary Syndrome

Objective To study the significance of NT-proBNP and hsCRP in patients with acute coronary syndromes （ACS）. Methods The study comprised 106 patients with ACS. Group Ⅰ consisted of 36 patients with unstable angina peetoris（UAP）. Group Ⅱ consisted of 37 patients with myocardial infarction without ST segment elevation （NSTEMI）. Group Ⅲ consisted of 33 patients with myocardial infarction with ST segment elevation（STEMI）. In all patients, NT-proBNP and hsCRP were determined, the data were compared with those of 30 healthy controls. Results In ACS, the levels of NT-proBNP and hsCRP were higher those of healthy controls. The level of NT-proBNP in NSTEMI group was higher than that in UAP group;the levels of NT-proBNP and hsCRP in STEMI group were higher than those in NSTEMI group and UAP group;the difference of level of hsCRP between NSTEMI group and UAP group was statistically significant （ P 〈 0.05 ）. Conclusion The severity of ACS can be evaluated the combination determination of NT-proBNP and hsCRP, which was important to the diagnosis, treatment and prognosis of the dis- ease.