| 4-氨基-5-氯-2-乙氧基-N-[[4-(4-氟苄基)-2-吗啉基]甲基]苯甲酰胺的合成 |
| |
| 引用本文： | 王付苍,姜自营.4-氨基-5-氯-2-乙氧基-N-[[4-(4-氟苄基)-2-吗啉基]甲基]苯甲酰胺的合成[J].齐鲁药事,2006,25(6):356-357. |
| |
| 作者姓名： | 王付苍 姜自营 |
| |
| 作者单位： | 1. 鲁南制药集团股份有限公司,临沂,276005;鲁南制药集团股份有限公司,临沂,276005
2. 鲁南制药集团股份有限公司,临沂,276005 |
| |
| 摘 要： | 目的合成4-氨基-5-氯-2-乙氧基-N-4-(4-氟苄基)-2-吗啉基]甲基]苯甲酰胺.方法以中间体4-氨基-5-氯-2-乙氧基苯甲酸和中间体B、C为原料合成目标产物.结果合成目标产物的收率为90·0%,提高近30·0%;中间体4-氨基-5-氯-2-乙氧基苯甲酸、中间体邻苯二甲酰亚胺钾、中间体B和中间体C为鲁南贝特制药有限公司生产确证.结论通过对合成路线的优化,使生产收率提高,降低成本,工艺更适于工业化的生产.
|
| 关 键 词： | 4-氨基-5-氯-2-乙氧基苯甲酸 莫沙必利 中间体 合成 |
| 文章编号： | 1672-7738(2006)06-0356-02 |
Synthesis of 4-Amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methy]Benzamide |
| |
| WANG Fu-cang.Synthesis of 4-Amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methy]Benzamide[J].qilu pharmaceutical affairs,2006,25(6):356-357. |
| |
| Authors: | WANG Fu-cang |
| |
| Abstract: | OBJECTIVE To synthesize 4-amino-5-chloro-2-ethoxy-N-4-(4- fluorobenzyl)-2- morpholinylmethy benzamide .METHODS The target compound was synthesized from 4-amino-5-chloro-2-ethoxy benzoic acid and intermediate B and C.RESULTS The yield of the target compound was improved to 90.0%,up to ahout 30.0%.All of the intermediates were made in Lu′nan Pharmaceutical Better Limited Corporation and verified by us.CONCLUSION The recycle rate was improved and the cost was decreased by changing the path of synthesis.And the technique is suitable for industrial production. |
| |
| Keywords: | 4-Amino-5-chloro-2-ethoxy benzoic acid Mosapride intermediate synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
