Subepicardial steal and reduction of myocardial oxygen consumption by adenosine |
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| Authors: | David C. Warltier Garrett J. Gross Harold F. Hardman |
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| Affiliation: | Department of Pharmacology and Toxicology, The Medical College of Wisconsin, P.O. Box 26509, Milwaukee, WI 53226, U.S.A. |
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| Abstract: | The direct effects of adenosine on cardiac oxygen balance, hemodynamics and regional myocardial perfusion were studied in isolated canine hearts. Intracoronary infusion of adenosine produced a dose-dependent shift in the transmural distribution of coronary blood flow away from left ventricular subendocardium and a reduction in myocardial oxygen consymption (MVO2). The data suggest that adenosine may partially decrease MVO2 by a redistribution of flow from a high to low oxygen-extracting region of the myocardium. |
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| Keywords: | Myocardial oxygen consumption Coronary steal Transmural myocardial blood flow |
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