Effect of iron,cobalt, and chromium dust on rabbit alveolar macrophages: A comparison with the effects of nickel dust |
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| Authors: | Anne Johansson Margot Lundborg Per-Åke Hellström Per Camner Thomas R Keyser Sarah E Kirton David FS Natusch |
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| Institution: | 1. Departments of Environmental Hygiene, Karolinska Institute and National Environment Protection Board, University of Stockholm, Stockholm, Sweden;2. Wenner-Gren Institute, University of Stockholm, Stockholm, Sweden;3. Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523 USA |
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| Abstract: | In a previous inhalation study, exposure of rabbits to concentrations of 0.5 to 2 mg/m3 of metallic nickel dust over a period of 4 weeks produced certain reproducible effects on their lungs. The weight and density of the lungs increased as well as the phagocytic activity and size distribution of the alveolar macrophages. Changes in the ultrastructure of the macrophages and the lung lavage fluid were also seen. In the present study, groups of four rabbits each were exposed to iron dust (0.4 and 1.4 mg/m3), cobalt dust (0.2 and 1.3 mg/m3), and chromium dust (0.6 and 3.1 mg/m3). None of these metals gave the same pattern of effects as the nickel dust. The particles, including the nickel particles, were studied with regard to morphology, surface and bulk composition, specific surface area, and solubility in fluids. The nickel on the nickel particles, together with manganese on the chromium particles were the most soluble components. Otherwise, the nickel particles did not differ substantially from the other particles. |
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