| 大剂量乌司他丁对大面积烧伤患者凝血功能的影响及意义 |
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| 引用本文： | 曹卫红,柴家科,杨红明,贾晓明,孙天骏,邹晓防,盛志勇. 大剂量乌司他丁对大面积烧伤患者凝血功能的影响及意义[J]. 感染、炎症、修复, 2005, 6(3): 162-164 |
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| 作者姓名： | 曹卫红 柴家科 杨红明 贾晓明 孙天骏 邹晓防 盛志勇 |
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| 作者单位： | 100037,北京,解放军总医院304临床部全军烧伤研究所临床部;100037,北京,解放军总医院304临床部全军烧伤研究所临床部;100037,北京,解放军总医院304临床部全军烧伤研究所临床部;100037,北京,解放军总医院304临床部全军烧伤研究所临床部;100037,北京,解放军总医院304临床部全军烧伤研究所临床部;100037,北京,解放军总医院304临床部全军烧伤研究所临床部;100037,北京,解放军总医院304临床部全军烧伤研究所临床部 |
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| 摘 要： | 目的：观察大剂量乌司他丁对大面积烧伤患者凝血功能的影响。方法：4例大面积烧伤患者入院后第3天起每天给予大剂量乌司他丁(60万U,4次/d),用药前及用药后1d、3d、7d、10d、14d,抽血观察血浆纤维蛋白原含量(Fib-c)、凝血酶原时间(PT)、凝血酶时间(TT)、部分凝血活酶时间(APTT)及血浆D-二聚体含量的变化。结果：用药前血浆D-二聚体及纤维蛋白原含量明显升高,PT时间显著延长；给予大剂量乌司他丁1d后,血浆D-二聚体及纤维蛋白原含量明显减低,PT时间迅速恢复。结论：大面积烧伤患者早期应用大剂量乌司他丁可显著改善凝血功能,预防播散性血管内凝血的发生。
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| 关 键 词： | 乌司他丁 重症烧伤 凝血功能 |
The influence of high dose ulinastatin on blood coagulation function in severely burned patients and its significance |
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| Cao Weihong Chai Jiake Yang Hongming,Burn,Institute,a first Affiliated Hospital to the PLA General,Hospital,Beijing. The influence of high dose ulinastatin on blood coagulation function in severely burned patients and its significance[J]. Infection Inflammation Repair, 2005, 6(3): 162-164 |
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| Authors: | Cao Weihong Chai Jiake Yang Hongming Burn Institute a first Affiliated Hospital to the PLA General Hospital Beijing |
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| Affiliation: | Cao Weihong Chai Jiake Yang Hongming,Burn,Institute,a first Affiliated Hospital to the PLA General,Hospital,Beijing 100037 |
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| Abstract: | Objective:To observe the influence of high dose ulinastatin on blood coagulation function in severely burned patients.Methods:Four patients were enrolled in this study,high dose ulinastatin (600,000U,q.i.d) was given intravenously after admission,the changes in PT,APTT,TT,and levels of fibrinogen as well as D-dimer were measured before and after treatment on days 1,3,5,7,9,and 11.Results:The levels of fibrinogen and D-di- mer.were dramatically high before treatment,and they were decreased rapidly on day 1 after treatment,the values of PT were also recovered on day 1 after treatment Conclusion:High dose ulinastatin can dramatically ameliorate blood coagulation disorder in early stage of severely burned patients,and prevent the development of disseminated introvascular coagulation (DIC). |
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| Keywords: | Ulinastatin Severe burn Blood coagulation |
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