| 结节性红斑及结节性血管炎患者血浆CD62P的表达 |
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| 引用本文： | 张春梅,李宝强,于立勤,孙立新. 结节性红斑及结节性血管炎患者血浆CD62P的表达[J]. 中国皮肤性病学杂志, 2004, 18(7): 412-413 |
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| 作者姓名： | 张春梅 李宝强 于立勤 孙立新 |
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| 作者单位： | 1. 承德医学院附属医院皮肤科,河北,承德,067000
2. 承德医学院附属医院中心实验室,河北,承德,067000 |
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| 摘 要： | 目的 探讨结节性红斑及结节性血管炎患者血小板活化功能。方法 应用流式细胞仪技术检测两种血管炎患者血浆CD62P表达。结果 与正常对照组相比,患者组CD62P表达量明显增高(P均<0.01);其中12例患者治疗后血染CD62P表达收治疗前明显下降(P<0.01),但仍高于对照组(P<0.01)。结论 血小板活化在结节性红斑及结节性血管炎的发生、发展中具有重要意义。
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| 关 键 词： | 结节性红斑 结节性血管炎 流式细胞仪 血小板 CD62P |
| 文章编号： | 1001-7089(2004)07-0412-01 |
Expression of CD62P on Platlets in Patients with Erythema Nodosum and Nodular Vasculitis |
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| ZHANG Chun-mei,LI Bao-qiang,YU Li-qin,et al. Expression of CD62P on Platlets in Patients with Erythema Nodosum and Nodular Vasculitis[J]. The Chinese Journal of Dermatovenereology, 2004, 18(7): 412-413 |
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| Authors: | ZHANG Chun-mei LI Bao-qiang YU Li-qin et al |
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| Affiliation: | ZHANG Chun-mei,LI Bao-qiang,YU Li-qin,et al Department of Dermatology,Affiliated Hospital,Chengde Medical College,Chengde 067000,China |
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| Abstract: | Obiective To explore the changes of platelet activation in erythema nodosum and nodular vasculitis pa-tients. Methods Platelet-activation molecules CD62P on platelets from 40 patients with cutaneous vasculitis was detectedby using flow cytometry. Results Compared with the normal control group,increased expression of CD62P on platlets from40 patients was observed(P<0. 01);Expression of CD62P on platlets from 12 patients after recovered was significantly de-creased compared with that of patients before treatment(P<0. 01), but was still higher than that of the normal controlgroup(P<0. 01). Conclusiou The results suggest that platelet activation may play an important role in pathogenesis of er-ythema nodosum and nodular vasculitis. |
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| Keywords: | Erythema Nodosum Nodular vasculitis Flow cytometry Blood platelet CD62P |
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