HGV/GBV-C infection in patients with acute hepatitis of different etiology and in patients with chronic hepatitis C |
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Authors: | Paolo Fabris Domenico Infantolino Maria Raffaella Biasin Paolo Benedetti Giulia Tositti Costanza Bettini Giuditta Marchelle Fausto de Lalla |
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Institution: | (1) Department of Infectious Diseases, Ospedale S. Bortolo, Viale Rodolfi, 36100-Vicenza, Italy, IT;(2) Department of Pathology, Ospedale Civile, Castelfranco Veneto, Italy, IT |
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Abstract: | To investigate the prevalence of hepatitis G virus (HGV/GBV-C) in patients with liver disease and to confirm its hypothesized
ability to cause liver damage, we studied 130 subjects; 61 had chronic hepatitis C virus infection and 69 had acute hepatitis
of either defined etiology (n = 57) or of unknown origin (n = 12). Positivity for HGV/GBV-C RNA was detected in 10 of the 61 subjects with chronic hepatitis C (16.3%) and in 11 of the
57 subjects with acute hepatitis of defined etiology (19%), whereas we failed to detect HGV/GBV-C viremia in subjects with
hepatitis of non-established etiology. Patients exhibiting positivity for HGV/GBV-C RNA were found to be comparable to those
exhibiting negativity for HGV/GBV-C RNA in terms of both liver function tests and Knodell's score (in liver biopsies); the
affect of HGV/GBV-C infection on the biohumoral and histological activity in patients with chronic hepatitis C therefore appears
to be minimal or absent. Similar clinical features were observed in patients with acute hepatitis of known etiology whether
they were positive or negative for HGV/GBV-C RNA. However, long-term clinical studies are still required to clarify the actual
impact of HGV/GBV-C co-infection. In our geographic, i.e., a region or north-east Italy, HGV/GBV-C infection appears to be
strictly related to intravenous drug use, and this agent does not seem to be responsible for acute hepatitis of unknown etiology;
other etiological agents are probably involved.
Received Feb. 17, 1997; accepted June 27, 1997 |
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Keywords: | : HGV/GBV-C chronic hepatitis C acute hepatitis |
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