舌鳞状细胞癌浸润方式与癌淋巴管生成的特点及临床意义

目的探讨不同浸润方式舌鳞状细胞癌淋巴管生成的特点及临床意义。方法 参照Anneroth等描述的肿瘤浸润方式对41例舌鳞状细胞癌进行分型,应用免疫组化法,以D2-40标记淋巴管,计数淋巴管密度（lymphatic vessel density,LVD）。结果不同浸润方式的舌鳞状细胞癌D2-40的表达不同,浸润方式为Ⅲ、Ⅳ型的舌鳞状细胞癌,淋巴管密度（LVD）显著高于Ⅰ、Ⅱ型（P〈0.05）,且临床易出现淋巴结转移。结论Ⅲ、Ⅳ型浸润方式的舌鳞状细胞癌恶性程度高,可能具有较强的诱导淋巴管生成的能力。

The characteristics and clinical significance of lymphangiogenesis in squamous cell carcinoma of the tongue with different patterns of invasion

Objective To investigate the characteristics and clinical significance of lymphangiogenesis in squamous cell carcinoma（SCC） of the tongue with different patterns of invasion.Methods A total of 41 cases with squamous cell carcinoma of the tongue were classified into four groups according to the pattern of invasion and the D2-40 expression was detected using immunohistochemistry.Results The expression of D2-40 in tongue SCC varied in accordance with the pattern of invasion.The LVD in tongue SCC of pattern Ⅲ and Ⅳ invasion had a higher level than that of pattern Ⅰ and Ⅱ,with statistical significance（P0.05）.The clinical findings showed that the rate of lymph node metastasis was easily involved in pattern Ⅲ and Ⅳ.Conclusion Tongue SCC of pattern Ⅲ and Ⅳinvasion may have a strong ability to induce lymphangiogenesis.