Stereoselective disposition of ibuprofen enantiomers in infants |
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| Authors: | E. Rey, A. Pariente-Khayat, L. Gouyet, F. Vauzelle-Kervroë dan, G. Pons, Ph. D'Athis, M. C. Dubois, I. Murat, C. Lassale, M. Goehrs, Cl. Saint-Maurice, G. Olive |
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| Affiliation: | E. Rey, A. Pariente-Khayat, L. Gouyet, F. Vauzelle-Kervroëdan, G. Pons, Ph. D'Athis, M. C. Dubois, I. Murat, C. Lassale, M. Goehrs, Cl. Saint-Maurice, and G. Olive |
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| Abstract: | The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 ± 0.3 mg kg-1 dose of the racemate in 11 infants. Mean (± s.d.) half-lives were 1.6 ± 0.5 h for S(+) and 1.5 ± 0.5 h for R(-) and mean (± s.d.) AUC values were 31.5 ± 14.3 mg l-1 h for S(+) and 36.6 ± 13.8 mg l-1 h for R(-). Since plasma concentrations of the active S(+)-isomer were lower than those reported in adults, a higher dosage might be required in infants. |
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