| 氯化四乙基铵及维拉帕米对家兔缺血心肌不应期的影响 |
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| 引用本文： | 裴建明,周士胜,牛国保,朱妙章,臧益民. 氯化四乙基铵及维拉帕米对家兔缺血心肌不应期的影响[J]. 药学学报, 1992, 27(10): 721-724 |
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| 作者姓名： | 裴建明 周士胜 牛国保 朱妙章 臧益民 |
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| 作者单位： | 第四军医大学生理学教研室，第四军医大学生理学教研室，第四军医大学生理学教研室，第四军医大学生理学教研室，第四军医大学生理学教研室 西安 710032，西安 710032，西安 710032，西安 710032，西安 710032 |
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| 摘 要： | 实验比较了K+通道阻断剂氯化四乙基铵(TEA)及Ca2+通道阻断剂维拉帕米(verapamil,Ver)对家兔缺血性心室肌不应期(ERP)的影响。结果表明,阻断冠脉10min及30min后,缺血中心区(CIZ)和缺血边缘区(BIZ)心肌ERP比缺血前均明显缩短,而TEA和Ver均能延长急性缺血性心肌的ERP,可能对心肌缺血引起的心律失常有预防作用。
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| 关 键 词： | 氯化四乙基按 维拉帕米 有效不应期 心肌缺血 |
| 收稿时间： | 1991-11-29 |
EFFECTS OF TETRAETHYLAMMONIUM CHLORIDE AND VERAPAMIL ON THE EFFECTIVE REFRACTORY PERIOD OF ISCHEMIC MYOCARDIUM IN RABBITS |
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| JM Pei,SS Zhou,GB Niu,MZ Zhu and YM Zang. EFFECTS OF TETRAETHYLAMMONIUM CHLORIDE AND VERAPAMIL ON THE EFFECTIVE REFRACTORY PERIOD OF ISCHEMIC MYOCARDIUM IN RABBITS[J]. Acta pharmaceutica Sinica, 1992, 27(10): 721-724 |
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| Authors: | JM Pei SS Zhou GB Niu MZ Zhu YM Zang |
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| Affiliation: | Department of Physiology, Fourth Military Medical University, Xian. |
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| Abstract: | The effects of potassium ion Channel blocker TEA and calcium ion channel blokerverapamil on effective refractory period (ERP) of ischemic ventricular muscle were studied in rabbits.The results showed that ERP of the ventricular muscle in central ischemic zone (CIZ) and border is-chemic zone (BIZ) wete shortened, respectively, at 10 min and 30 min after coronary occlusion(P<0. 01). The changes of ERP in TEA--treated and verapamil--treated rabbits after coronary oc-clusion were found to be significantly less than those in untreated rabbits. The results suggest that TEAand verapamil alleviated the degree of ERP shortening after coronary occlusion and may exhibit protec-tive effects on the ischemic myocardium. |
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| Keywords: | Tetraethylammonium chloride Verapamil Effective refractory period Myocardial ischemia |
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