| 硒、钼、硼对氟中毒大鼠成釉细胞形态及PCNA、C-myc表达变化的影响 |
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| 引用本文： | 汤晔,陈黎明.硒、钼、硼对氟中毒大鼠成釉细胞形态及PCNA、C-myc表达变化的影响[J].贵州医药,2011,35(8):687-690. |
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| 作者姓名： | 汤晔 陈黎明 |
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| 作者单位： | 贵阳市口腔医院,550002 |
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| 基金项目： | 贵阳市社会发展攻关计划基金资助[筑科农合(2009)3-039号] |
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| 摘 要： | 目的 观察硒、钼、硼对氟中毒大鼠成釉细胞形态及增殖细胞核抗原(PCNA),C-myc 基因表达变化的影,气方法大鼠分组均喂以含F-45 mg/L的蒸馏水及含不同浓度硒、钼、硼的饲料,建立微量元素拮抗氟中毒的大鼠模型.采用HE染色及免疫组化的方法观察氟对成釉细胞的影响,采用图像分析技术时免疫组化结果进行量化分析.结果 实...
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| 关 键 词： | 氟中毒 硒 钼 硼 拮抗 PCNA C-myc |
Effect of Selenium,molybdenum and boron on ameloblast morphology and the expression of PCMA,C-MYC in fluorosis rat |
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| Tang Ye,Chen Liming.Effect of Selenium,molybdenum and boron on ameloblast morphology and the expression of PCMA,C-MYC in fluorosis rat[J].Guizhou Medical Journal,2011,35(8):687-690. |
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| Authors: | Tang Ye Chen Liming |
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| Institution: | Tang Ye,Chen Liming.Dental Hospital of Guiyang City,Guiyang,550002,China |
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| Abstract: | Objective To study the effects of selenium,molybdenum,and boron on ameloblast morphology and the expression of PCNA,c-myc in fluorosis rat. Methods Each groups were drinking fluoride(F ˉ)45 mg / L of distilled water and fed with containing different concentrations of selenium,molybdenum,boron except control group.Observed the changes of ameloblasts morphological by light microscopy,detected the expression of PCNA and c-myc in ameloblast by immunohistochemistry.The semiquantitatively analyze of PCNA,c-myc were done by image analysis software. ResultsThere are more normal morphology of ameloblasts in experimental groups,and PCNA expression increased,c-myc expression decreased. Conclusion The mechanism of Selenium,molybdenum,and boron reducing fluoride toxicity may relate to the fluoride antagonistic effects that enhancement of c-myc expression and inhibition of PCNA expression. |
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| Keywords: | Fluorosis Selenium Molybdenum B Antagonistic PCNA C-myc |
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