CD105和HIF-la在侵袭性垂体瘤中的表达

目的 研究CD<,105>和缺氧诱导因子-la (HIF-la)在侵袭性垂体瘤中的表达水平,并探讨CD<,105>标记的MVD密度及HIF-la在侵袭性垂体瘤中的生物学意义和作用.方法 收集2005-2010年的侵袭性垂体瘤手术标本25例,非侵袭性垂体瘤15例,用免疫组化方法检测CD<,105>及HIF-la的表达,并...

Expression of CD105 and hypoxia inducible factor-1α （HIF-1α） in invasive pituitary tumors

Objective To study the expression of CD105 and hypoxia-inducible factor 1a(HIF-1α) in the invasive pituitary tumor and to explore the biological significance and role of microvessel density(MVD) marked by CD105 and that of HIF-1α in the invasive pituitary tumor.Methods Twenty five surgical specimens from cases with invasive pituitary tumors and fifteen surgical specimens from cases of non-invasive pituitary tumors were collected from 2005 to 2010.Immunohistochemical technique was used to detect the expression of CD105 and HIF-1α,and the MVD marked by CD105 was counted.Comparison analysis was performed on the data obtained.Results All the specimens were found to express CD105.The mean CD105-MVD value of the 40 cases was(16.2±6.1),which was(21.8±2.8) in the invasive group and(10.6±2.2) in the non-invasive group.HIF-1α expression analysis showed 14 cases(+) and 11 cases(-) in the invasive group,and 3 cases(+) and 12 cases(-) in the non-invasive group.Statistical analysis revealed the differences of the expression of CD105 and HIF-1α between the two groups was statistically significant(P<0.05).Conclusion The CD105 and HIF-1α expression in the invasive pituitary tumor is significantly higher than that in the non-invasive group,which indicates that CD105 and HIF-1α are involved in the occurrence and development of invasive pituitary tumor.CD105 and HIF-1α could serve as immunological detection indicators for predicting the invasiveness of pituitary tumor.