| 亚硒酸钠对大鼠脑缺血再灌注后行为学和梗死灶体积的影响 |
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| 引用本文： | 王光胜,王元伟,陈孝东,顾汉沛,耿德勤. 亚硒酸钠对大鼠脑缺血再灌注后行为学和梗死灶体积的影响[J]. 海南医学, 2011, 22(17): 27-29 |
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| 作者姓名： | 王光胜 王元伟 陈孝东 顾汉沛 耿德勤 |
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| 作者单位： | 1. 徐州医学院附属医院神经内科,江苏徐州,221002
2. 沭阳县人民医院神经内科,江苏 沭阳,223600 |
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| 摘 要： | 目的观察亚硒酸钠对大鼠脑缺血再灌注损伤后行为学和梗死灶体积的影响。方法63只SD大鼠随机分为假手术组、缺血再灌注组（模型组）及亚硒酸钠治疗组，每组21只，采用线栓法建立脑缺血再灌注模型。观察亚硒酸钠治疗前后大鼠行为学评分变化，于再灌注3d后亚甲兰染色观察海马CA1区神经细胞数量变化；进一步计算出脑组织含水量，TTC染色后测定脑梗死灶体积。结果模型组与亚硒酸钠治疗组治疗前大鼠行为学评分差异无统计学意义，亚硒酸钠治疗组与模型组比较，缺血再灌注后24h神经功能缺损即明显改善（P〈0．05），72h神经功能改善更显著（P〈0．01）。脑缺血再灌注损伤的大鼠海马神经细胞数目明显减少，亚硒酸钠治疗后海马神经细胞存活数目明显增多；治疗组与模型组相比，亚硒酸钠可以明显减少梗死灶体积（P〈0．01）。与假手术组及非梗死侧大脑半球脑组织含水量比较，大鼠梗死侧脑组织含水量明显增加（P〈0．05）；与模型组比较，亚硒酸钠治疗后梗死区脑组织含水量明显降低（P〈0．05）。结论亚硒酸钠能显著减轻大鼠脑梗死灶体积，从而改善神经功能症状，对脑缺血再灌注损伤有保护作用。
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| 关 键 词： | 亚硒酸钠 缺血再灌注损伤 脐梗死体积 大鼠 |
Effect of Na_2 SeO_3 on behavior and infarct size after cerebral ischemia-reperfusion(IR) injury in rats |
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| WANG Guang-sheng,WANG Yuan-wei,CHEN Xiao-dong,GU Han-pei,GENGDe-qin. Effect of Na_2 SeO_3 on behavior and infarct size after cerebral ischemia-reperfusion(IR) injury in rats[J]. Hainan Medical Journal, 2011, 22(17): 27-29 |
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| Authors: | WANG Guang-sheng WANG Yuan-wei CHEN Xiao-dong GU Han-pei GENGDe-qin |
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| Affiliation: | WANG Guang-sheng 1,WANG Yuan-wei 2,CHEN Xiao-dong 2,GU Han-pei 1,GENG De-qin 1.1.Department of Neurology,The Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,Jiangsu,CHINA.2.Department of Neurology,the People's Hospital of Shuyang,Shuyang 223600,CHINA. |
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| Abstract: | Objective To observe the effects of sodium selenite(Na 2 SeO 3) on the behavior and infarct size af-ter cerebral ischemia-reperfusion(IR) injury in rats.Methods 63 Sprague-Dawley(SD) rats were randomly divided into three groups,the sham-operated group,IR group and the Na 2 SeO 3 group,with 21 rats in each group.In the latter two groups,cerebral IR injury was induced by middle cerebral artery occlusion.The changes of behavior scores before and after the Na 2 SeO 3 treatment in each group were studied,and the... |
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| Keywords: | Sodium selenite(Na 2 SeO 3) Ischemia-reperfusion(IR) injury Infarct size Rat |
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