| 膀胱癌组织中MMP9、MMP2与PCNA及临床指标的研究 |
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| 引用本文： | 彭东涛,苟欣,何梓铭. 膀胱癌组织中MMP9、MMP2与PCNA及临床指标的研究[J]. 重庆医科大学学报, 2003, 28(4): 467-469 |
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| 作者姓名： | 彭东涛 苟欣 何梓铭 |
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| 作者单位： | 重庆医科大学临床学院泌尿外科,重庆,400016 |
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| 摘 要： | 目的：探讨基质金属蛋白酶(MMP9、MMP2)在膀胱癌组织中的表达及意义。方法：采用免疫组织化学S—P法检测64例人膀胱移行细胞癌(TCCB)石蜡切片中MMP9、MMP2的表达。结果：64例TCCB组织中，MMP9、MMP2的阳性表达率分别为60．93％(39／64)、42．19％(27／64)；且MMP9的阳性表达率与肿瘤的病理分级和分期，以及肿瘤的大小及PCNA的阳性表达率相关；与年龄、性别、肿瘤数目无关。结论：MMP9的表达可以作为估计TCCB的预后及术后综合治疗的生物学指标。
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| 关 键 词： | 膀胱肿瘤 基质金属蛋白酶 免疫组织化学 |
| 文章编号： | 0253-3626(2003)04-0467-03 |
| 修稿时间： | 2002-09-02 |
Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder |
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| PENG Dongtao,et al. Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder[J]. Journal of Chongqing Medical University, 2003, 28(4): 467-469 |
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| Authors: | PENG Dongtao et al |
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| Abstract: | Objective:To study the expression and clinical significance of matrix metalloproteinase(MMP9,MMP2)in transitional cell carcinoma of bladder(TCCB).Methods:Applying S-P immunohistochemical technique,expression of MMP9 and MMP2 was studied in 64 TCCB.Results:There was 60.93%(39/64) with MMP9 and 42.19%(27/64) with MMP2 expression.There was a significant correlation between MMP9 expression and PCNA,pathological grade,clinical stage,tumor size.However,the relationship had not been found with patient age,sex as well as the number of tumor.Conclusion:MMP9 appears to be an independent biological marker for predicting prognosis and comprehensive treatment of TCCB. |
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| Keywords: | Bladder neoplasms Matrix metalloproteinase Immunohistochemistry |
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