大蒜素抗溃疡及通便作用研究

目的研究大蒜素抗溃疡作用和对排便作用的影响。方法采用乙醇/盐酸大鼠胃溃疡模型、幽门结扎型溃疡模型、消炎痛致溃疡模型及乙酸致胃溃疡等模型,观察动物溃疡指数;采用燥结失水便秘模型,观察动物排便时间及排便点数;采用正常小鼠碳末推进实验,观察小鼠小肠运动功能。结果大蒜素能减少乙醇/盐酸大鼠胃溃疡模型、幽门结扎型溃疡模型、消炎痛致溃疡模型及乙酸致胃溃疡等模型的溃疡指数(P<0.05或P<0.01);能使模拟燥结的失水便秘模型小鼠的排便时间缩短,排便点数增加(P<0.05或P<0.01);能增加正常小鼠小肠碳末推进的百分率(P<0.05或P<0.01)。结论大蒜素具有抗溃疡及促进排便作用。

Effects of alltride on gastric ulcer and promoting bowl movement

AIM: To study the effects of alltride on experimental gastric ulcer and promoting bowl movement. METHODS: Applying experimental gastric ulcer models induced by alcohol and hydrochloric acid, ligating pylorus, indomethacin, acetic acid, calculated the index of gastric ulcer. Applying dry stool constipations in mice the first defecation time, moist dejection amounts were observed. In small intestinal propelling test in normal mice, small intestinal contents (charcoal Powder) propelling ratio was observed. RESULTS: Alltride reduced the index of ulcers in above experimental gastric ulcer model rats (P< 0.05 or P< 0.01 ). KZS shortened the first defecation time and increase moist dejection amounts in dry stool constipations mice and improve apparently intestinal peristalsis (P< 0.05 or P< 0.01 ). CONCLUSION: Alltride has antiulcer effects in rats and the action of moistening the intestines and promoting bowl movement.