注射用头孢哌酮钠与5种常用输液的配伍稳定性分析

目的研究在室温20℃条件下注射用头孢哌酮钠与5种常用输液的配伍稳定性。方法将头孢哌酮钠加入5种输液中,配制成浓度为4mg·mL^-1的溶液。在室温20℃下,于配伍后0、0.5、1、2、4、8h时用高效液相色谱法测定浓度,同时观察PH值及外观变化。结果配制后8h头孢哌酮钠在木糖醇注射液、0.9%氯化钠注射液中含量分别为98.96%、98.77%;在5%葡萄糖注射液、5%葡萄糖氯化钠注射液、10%葡萄糖注射液中含量有所下降,分别为96.55%、97.62%、96.43%。结论注射用头孢哌酮钠在木糖醇注射液、0.9%氯化钠注射液中稳定性最好,建议临床配伍使用。

Stability analysis of combined cefoperazone sodium for injection with five infusions

OBJECTIVE Study the compatibility stability between Cefoperazone sodium for injection and five kinds of common used infusion.METHODS Joining the cefoperazone sodium in the five kinds of infusion,and Preparing 4mg/mL solution.At room temperature under 20℃,content determination was performed at indicated time of 0、0.5、1、2、4、8h after combination by high-performance liquid chromatography.At the same time changes in concentration,pH value and appearance were observed.RESULTS After preparation,the content of Cefoperazone sodium for injection in the xylitol,0.9% sodium chloride injection were 98.96%,98.77% along with the time within 8h;8h after the preparation of cefoperazone sodium in the xylitol injection,0.9%sodium chloride injection concentration were 98.96%,98.77%;In 5% glucose injection,5% glucose and sodium chloride injection,10% glucose injection levels was decreased to 96.55%、97.62%、96.43%.CONCLUSION Cefoperazone sodium for injection in xylitol and 0.9% sodium chloride injection in the stability of the best,it is recommended the use of compatibility in clinical.