| TPF诱导化疗治疗局部晚期鼻咽癌的Ⅰ期临床研究 |
| |
| 引用本文： | 郭灵,林焕新,徐敏,陈秋燕,王成涛,黄培钰. TPF诱导化疗治疗局部晚期鼻咽癌的Ⅰ期临床研究[J]. 癌症, 2010, 29(2): 143-147 |
| |
| 作者姓名： | 郭灵 林焕新 徐敏 陈秋燕 王成涛 黄培钰 |
| |
| 作者单位： | 华南肿瘤学国家重点实验室;中山大学肿瘤防治中心鼻咽癌科;中山大学肿瘤防治中心放疗科; |
| |
| 摘 要： | 背景与目的:PF方案是治疗晚期头颈部癌包括晚期鼻咽癌的标准方案,近年发现泰素帝加PF的TPF方案可提高其疗效。本研究旨在探讨TPF诱导化疗治疗晚期鼻咽癌的剂量限制毒性(dose-limiting toxicity,DLT)和最大耐受剂量(maximum tolerated dose,MTD),同时观察疗效。方法:从2006年12月至2008年5月,共有41例初诊局部晚期(UICC分期Ⅲ、Ⅳ期)鼻咽癌患者入组,其中男性29例,女性12例,中位年龄47岁(29～60岁),ECOG体力状况评分≤2。TPF方案起始剂量为泰素帝40mg/m2d1,顺铂40mg/m2d1,氟尿嘧啶400mg/m2d1～5,每3周重复,共2个周期。泰素帝和顺铂每剂量级增加5mg/m2,氟尿嘧啶增加50mg/(m2·d)。每个剂量组至少收治6例患者,6例患者全部完成2个疗程化疗后并进行不良反应评价再进行剂量升级。第5周开始放射治疗,鼻咽原发病灶68～72Gy/34～36次,7周,颈部淋巴结阳性区60～66Gy/30～33次,6～6.5周。结果:41例患者共完成80周期化疗。40例(79个疗程)可评价疗效和不良反应。第1～4剂量组均未出现DL...
|
| 关 键 词： | 鼻咽肿瘤 诱导化疗 放射疗法 泰素帝 顺铂 氟尿嘧啶 |
Phase I study of TPF neoadjuvant chemotherapy followed by radical radiotherapy in advanced nasopharyngeal carcinoma |
| |
| Ling Guo,,Huan-Xin Lin,,Min Xu,Qiu-Yan Chen,Cheng-Tao Wang,Pei-Yu Huang,.State Key Laboratory of Oncology in South China,Guangzhou,Guangdong ,P.R.China. Phase I study of TPF neoadjuvant chemotherapy followed by radical radiotherapy in advanced nasopharyngeal carcinoma[J]. Chinese journal of cancer, 2010, 29(2): 143-147 |
| |
| Authors: | Ling Guo Huan-Xin Lin Min Xu Qiu-Yan Chen Cheng-Tao Wang Pei-Yu Huang .State Key Laboratory of Oncology in South China Guangzhou Guangdong P.R.China |
| |
| Affiliation: | Ling Guo1,2,Huan-Xin Lin1,3,Min Xu1,Qiu-Yan Chen1,Cheng-Tao Wang1,Pei-Yu Huang1,21.State Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.China 2.Department of Nasopharyngeal Cancer,Sun Yat-sen University Cancer Center,P.R.China 3.Department of Radiation Oncology,P.R.China |
| |
| Abstract: | Background and Objective:PF regimen is the standard chemotherapy for advanced head and neck cancers including nasopharyngeal cancer.Recently PF has been found to enhance the tumor control by addition of taxotere.The purpose of this study was to evaluate the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of TPF neoadjuvant regimen [taxotere,cisplatin (DDP) and 5-fluorouracil (5-FU)] followed by radical radiotherapy in advanced nasopharyngeal carcinoma (NPC).Methods:Between December 2006 and Ma... |
| |
| Keywords: | Nasopharyngeal carcinoma neoadjuvant chemotherapy radiotherapy docetaxel cisplatin 5-fluorouracil |
| 本文献已被 CNKI 等数据库收录！ |
|
