| P-糖蛋白与难治性癫(癎)的相关性研究进展 |
| |
| 引用本文： | 许淑静. P-糖蛋白与难治性癫(癎)的相关性研究进展[J]. 国际儿科学杂志, 2010, 37(6). DOI: 10.3760/cma.j.issn.1673-4408.2010.06.023 |
| |
| 作者姓名： | 许淑静 |
| |
| 作者单位： | 河南省人民医院儿科,郑州,450003 |
| |
| 摘 要： | 癫(癎)耐药机制的研究已引起越来越多人的重视.P-糖蛋白(P-glycoprotein,Pgp)是近年来研究的热点之一,在体内主要起转运作用,其编码基因的多态性也影响着它的表达.该文从Pgp的编码基因多态性、多药转运蛋白假说、浓度平衡转运学说、Pgp抑制后效应方面就Pgp与癫(癎)耐药的相关性进行综述.
|
| 关 键 词： | P-糖蛋白 难治性癫(癎) |
Progress in the relationship between P-glycoprotein and refractory epilepsy |
| |
| XU Shu-jing. Progress in the relationship between P-glycoprotein and refractory epilepsy[J]. International Journal of Pediatrics, 2010, 37(6). DOI: 10.3760/cma.j.issn.1673-4408.2010.06.023 |
| |
| Authors: | XU Shu-jing |
| |
| Abstract: | The research of epilepsy drug-resistant mechanism has been paid more and more attention. Pglycoprotein(Pgp) ,being one of the hot points of recent research,plays the transporting role in the body,and its coding genetic polymorphism also affects its expression. The relationship between Pgp and drug-resistant epilepsy is reviewed based on the coding genetic polymorphisms, multidrug transporters hypothesis, concentration equilibrium transport assay, and Pgp inhibition effect. |
| |
| Keywords: | P-glycoprotein Refractory epilepsy |
| 本文献已被 万方数据 等数据库收录！ |
|
