补充维生素B_1、B_2及C对大鼠脑功能的影响

用普通奶粉和强化维生素Ｂ１、Ｂ２及Ｃ的奶粉进行对比实验，观察补充维生素对大鼠脑功能的影响。补充维生素后大鼠行为功能测试表明：错误反应率和逃避时间均明显下降，海马乙酰胆碱神经递质明显增加，脑脂质过氧化物水平降低（Ｐ＜０．０５），而大鼠身体发育无明显改变。提示，在满足机体发育下适当补充维生素Ｂ１、Ｂ２和Ｃ可改善脑功能。

EFFECTS OF VITAMIN B1、B2、C SUPPLEMENT ON BRAIN FUNCTION IN RATS

The　effects　of　vitamin　B1、B2、C　on　the　ability　of　learning　and　remenbrance　in　rats　were　investigated. Sixteen　weanling　Wistar　rats　were　divided　randomly　into　two　groups:(1)experimental　group(EG):milk　powder　was　fortified　with　vitamin　B1　4mg/100g,B2　4mg/100g,C　250mg/100g,(2)control　group(CG):milk　powder.The　results　of　electric　maze　tests　indicated　that　the　abilities　of　learning　and　remembrance　of　EG　group　was　significantly　higher　than　those　of　CG　group.The　content　of　the　acetylcholine　in　hippocampus　of　EG　group　was　significantly　higher　than　those　of　CG　group.The　total　protein　content　of　brain　in　EG　group　was　higher　than　CG　group.The　lipid　peroxide　content　of　brain　in　EG　group　was　lower　markedly　as　compared　with　CG　group.No　significant　differences　were　observed　in　body　weight,and　the　weight　of　whole　brain　and　hippocampus　between　the　two　groups. These　results　indicate　that　the　adequate　dosage　of　vitamin　B1、B2　and　C　supplement　can　increase　brain　function　of　learning　and　remenbrance.