营养缺乏及补充维生素A对大鼠肺巨噬细胞功能的影响

采用Ｗｉｓｔａｒ大鼠，从怀孕１６天进行限食喂养直到生后４５天，干预组从生后第３６天及第４２天分别给予维生素Ａ灌胃，每次２０００ＩＵ。结果表明，补充维生素Ａ可明显增加大鼠的胸腺重量、肺巨噬细胞的数目、巨噬细胞的吞噬功能及ＮＯ－２的分泌。维生素Ａ可部分纠正营养缺乏导致的免疫缺陷、胸腺萎缩，活化肺巨噬细胞功能，其作用机制有待于进一步研究。

MALNUTRITION AND SUPPLEMENTATION OF VITAMIN A ON FUNCTIONS OF ALVEOLAR MACROPHAGES

With higher phagocytosis and antimicrobiological functions alveolar macrophages play an important role in the lung defence.Rats were food restricted with 75% and 50% of the control diet consumpation from the 16th day of pregnancy to the 45th day after delivery and supplemented with vitamin A 2000IU once a day at the 36th day and the 41th day post partum.Results indicated that food restriction could decrease the spleen and thymus weight,impair phagocytosis of neutral red and secretion of NO by alveolar macrophages.Vitamin A oral supplementation could partially restore the immunosuppression caused by malnutrition,especially increase thymus weight and action of alveolar macrophages.This mechanism is required for further research.