| 急性缺氧对大鼠脂质过氧化的影响及补充维生素E的效应 |
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| 引用本文： | 陈东升,杨家驹.急性缺氧对大鼠脂质过氧化的影响及补充维生素E的效应[J].营养学报,1997,19(1):28-31. |
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| 作者姓名： | 陈东升 杨家驹 |
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| 作者单位： | 第三军医大学营养卫生学教研室，利物浦大学，成都军区军事医学研究所 |
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| 摘 要： | 从４０００～６０００ｍ的不同模拟高度以及同一高度不同停留时间，观察缺氧对大鼠脂质过氧化的影响及维生素Ｅ干预的效应。结果表明，不同程度的缺氧能明显地增加多核粒细胞（ＰＭＮｓ）Ｏ－．２的产量，导致机体的脂质过氧化（ＬＰＯ）反应显著增强，其代谢产物丙二醛（ＭＤＡ）含量同步增高，但同一高度，缺氧时间长短作用不大。补充维生素Ｅ３０ｍｇ／ｄ，能有效地减轻ＬＰＯ反应，使动物血清ＭＤＡ含量显著下降，但补充ＶＥ对ＰＭＮｓＯ－．２产量无明显影响，说明ＶＥ抗ＬＰＯ很可能是阻断自由基反应，而不是降低自由基产量。
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| 关 键 词： | 急性缺氧 脂质过氧化 维生素E |
THE INFLUENCE OF PLATEAU ACUTE HYPOXIA ON LIPID PEROXIDATION OF RATS AND THE EFFECTS OF VITAMIN E SUPPLEMENTATION |
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| Cheng Dongsheng,Yang Jiaju,Zhu Jundong,Shi Yuangang,Zhang Qianyong,Fan Ye.THE INFLUENCE OF PLATEAU ACUTE HYPOXIA ON LIPID PEROXIDATION OF RATS AND THE EFFECTS OF VITAMIN E SUPPLEMENTATION[J].Acta Nutrimenta Sinica,1997,19(1):28-31. |
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| Authors: | Cheng Dongsheng Yang Jiaju Zhu Jundong Shi Yuangang Zhang Qianyong Fan Ye |
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| Abstract: | The influence of acute hypoxia on lipid peroxidation(LPO)of rats at different simulated altitudes (0,4000,6000m)and at the same simulated altitude (6000m) for staying different times(8,12,24h) were studied.The results showed that the intensity of hypoxia was positively conincided with the production of polymorphonuclear (PMNs)O - 2 and the LPO,but no significant increase at the same altitude by exposing for different times.The LPO wat reduced markedly by 30mg/d vitamin E supplementation,but the PMNs O . 2 did not significantly decrease.It is most likely that vitamin E exerts the anti LPO effect by only blocking the free radical reaction. |
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| Keywords: | acute hypoxia lipid peroxidation vitamin E |
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