Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists |
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Authors: | Aline G. M. Fraga Carlos R. Rodrigues Ana L. P. de Miranda Eliezer J. Barreiro Carlos A. M. Fraga |
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Abstract: | This paper describes the synthesis and the antiplatelet properties of new heterotricyclic N-acylhydrazone derivatives (7a–e), structurally analogous to known hetrazepinic PAF antagonists, exploring molecular hybridization as a tool for molecular designing. The synthetic route employed to access compounds (7a–e) used, as starting material, the previously described methyl 3-hydroxy-8-methyl-6-phenyl-6H-pyrazolo[3,4-b]thieno[2,3-d]pyridine-2-carboxylate derivative. The results from inhibitory effects of these novel acylhydrazone derivatives (7a–e) upon PAF-induced platelet aggregation, indicated that all compounds present a significant antithrombotic profile. |
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Keywords: | PAF antagonists N-Acyl hydrazone Pyrazolo[3,4-b]thieno[2,3-d]pyridine derivatives Antithrombotic activity |
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