| 血清甲状腺球蛋白测定与甲状腺疾病 |
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| 引用本文： | 高杰,安振梅.血清甲状腺球蛋白测定与甲状腺疾病[J].国际内分泌代谢杂志,2010,30(Z1). |
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| 作者姓名： | 高杰 安振梅 |
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| 作者单位： | 四川大学华西医院内分泌代谢科,成都,610041 |
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| 摘 要： | 甲状腺球蛋白(Tg)是自身免疫性甲状腺疾病(AITD)的主要自身抗原.各种甲状腺疾病均可出现Tg浓度异常.血清Tg测定对分化型甲状腺癌(DTC)复发或转移的诊断和疗效的监测有重要意义.但是Tg的测定受多种因素影响,其中甲状腺球蛋白抗体(TgAb)的干扰在临床上最常见.另外,不同甲状腺疾病Tg抗原表位不同,Tg基因多态性与甲状腺疾病也有一定关系.
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| 关 键 词： | 甲状腺球蛋白 自身免疫性甲状腺疾病 甲状腺球蛋白抗体 分化型甲状腺癌 抗原表位 基因多态性 |
Measurement of thyroglobulin and thyroid disease |
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| GAO Jie,AN Zhen-mei.Measurement of thyroglobulin and thyroid disease[J].International JOurnal of Endocrinology and Metabolism,2010,30(Z1). |
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| Authors: | GAO Jie AN Zhen-mei |
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| Abstract: | Thyroglobulin (Tg) is a major autoantigen for autoimmune thyroid disease (AITD) and serum Tg is used as a tumor marker to detect recurrent or metastasis disease in patients with differentiated thyroid carcinoma(DTC). But many factors, especially Tg antibody (TgAb) may interfere the measurement of Tg. In addition,thyroglobulin epitopes are different in thyroid diseases, and gene polymorphism is related to thyroid diseases. |
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| Keywords: | Thyroglobulin Autoimmune thyroid disease Thyroglobulin autoantibody Differentiated thyroid carcinoma Thyroglobulin epitopes Gene polymorphism |
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