急性胰腺炎患者血脂水平临床分析

目的分析急性胰腺炎(acute pancreatitis,AP)患者血脂、脂蛋白的变化,探讨高脂血症在急性胰腺炎发生发展中的作用。方法回顾性分析2005年6月～2008年6月AP共92例,AP患者入院24 h内及治疗后7～10d时由全自动生化分析仪检测血脂水平,包括总胆固醇(TC)、总甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)。结果轻、重症AP患者TG升高,HDL下降;治疗10 d后,轻型急性胰腺炎(mild acute pancreatitis,MAP)患者血TG、HDL水平恢复正常,急性重症胰腺炎(SAP)患者血TG仍维持高水平,HDL略有升高。高脂血症性急性胰腺炎TG水平高于胆源性、洒精性胰腺炎(P<0.01)。结论甘油三酯(TG)升高为主的高脂血症是AP的发病因素之一,血脂水平可作为AP严重程度的预测指标,临床降血脂治疗对AP防治有重要作用。

Clinical Analysis on the Level of Blood Lipids in Patients with Acute Pancreatitis

Objective To analyse the changes in blood lipids and lipoproteins in patients with acute pancreatitis (AP)and explore the influence of hyperlipemia on the development ofAP.Method The information of 92 cases with AP treated in our hospitol from June 2005 to June 2008 was analyzed.The level of serum lipid in patients with AP who were hospitalized in our hospital in 24 hours and after 7-10 days treatment was measured by Automatic Biochemical Analyzer,including the total cholesterol(TC),total triglyceride(TG),high density lipoprotein (HDL),and low density lipoprotein(LDL).The level of serum lipid in 30 healthy cases was also observed.Result The level of blood TG in mild acute pancreatitis(MAP)and severe acute pancreatitis(SAP)was higher than that in control group,while the level of blood HD reduced.The level of blood TG and HDL in patients with MAP turned to be normal after 10 days' treatment,but the serum lipid in patients with SAP was still high.Compared with biliogenpancreatitis and alcoholicpancreatitis,the level of blood TG in hyperlipidemicpancreatitis was significantly higher.Conclusion Hypertriglyceridemia is one of the factors leading to acute pancreatitis,and the level of blood lipids can predict the severity of AP.Reduction of blood lipid is important for patients with AP in clinic.