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Autoimmune hepatitis overlapping with primary sclerosing cholangitis
Authors:Takiguchi Junko  Ohira Hiromasa  Rai Tsuyoshi  Shishido Shoichiro  Tojo Jun  Sato Yukio  Kasukawa Reiji  Watanabe Hiroshi  Funabashi Yuji  Kumakawa Hiromi
Institution:Second Department of Internal Medicine, Fukushima Medical University School of Medicine.
Abstract:A case of autoimmune hepatitis (AIH) complicated by primary sclerosing cholangitis (PSC) in a 36-year-old woman is reported. AIH overlapping with PSC has been rarely reported, and to the best of our knowledge, there have been no reports in Japan. Based on the criteria for diagnosis of AIH and on typical endoscopic retrograde cholangiograph (ERC) findings, the patient was diagnosed as having AIH overlapping with PSC. Her transaminase levels normalized within 1 month after administration of prednisone, azathioprine and ursodeoxycholic acid, but her cholestatic enzyme level remained elevated. The effect of treatment on the cholestatic features is thought to be an important factor for predicting the prognosis of AIH overlapping with PSC.
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