复方丹参注射液治疗新生儿缺氧缺血性脑病临床观察

目的 观察复方丹参注射液治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法 患者随机分为两组,均给予吸氧,维持液体、电解质及酸碱平衡,止惊、降颅压、维护良好循环等支持对症综合治疗。复方丹参注射液组在以上常规治疗基础上加用复方丹参注射液6~10 ml,每日1次,加入10％葡萄糖液体50~100ml静脉滴注,连用7~10天。结果 复方丹参注射液组患者用药后显效率80％,总有效率96.6％,对照组显效率42.8％,总有效率78.5％,两组显效率及总有效率有显著差异(P<0.05)。经6~14个月随访,治疗组及对照组后遗症分别为2例和7例。结论 复方丹参注射液对新生儿缺氧缺血性脑病有较好疗效,能促进神经功能恢复,有利于HIE的恢复和改善预后。

Clinical research of the effect of Dan-shen root injection on hypoxia-ischemic encephalopathy of neonates

Objective To explore the therapeutic efficacy of Dan-shen root on hypoxia-ischemic encephalopathy of neonates. Methods Patients were randomized into two groups. Both groups were given support and routine treatment as giving oxygen,maintaining the quantity of liquid, withholding convulsion, reducing the intracranial pressure,sustaining the circulation. Dan-shen root injections were added in terms of routine treatment as Dan-shen root injection group. Dan-shen root injections,ranging from 6 to 10 ml and mixed with 50 or 100 ml 10% glucose, were administered daily and lasted for 7 or 10 days. Results The marked effect of Dan-shen root injection was 80% ,and the total effect was 96.6% . 42. 8% accounted for the controlled group with total effect of 78. 5% . There was some discrepancy between the two groups (P<0. 05). A follow-up study of 6 to 14 months exposed that there were two cases of sequela in treated groups and 7 cases of sequela in controlled group. Conclusion Dan-shen root injection is effective alternative for treating neonates with hypoxia-ischemic encephalopathy and it can facilitate nerve functional recover with preferable prognosis.