| 盐酸度洛西汀的合成 |
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| 引用本文： | 虞心红,温新民,汤建,毛庆华,沈永嘉. 盐酸度洛西汀的合成[J]. 中国医药工业杂志, 2006, 37(6): 367-369 |
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| 作者姓名： | 虞心红 温新民 汤建 毛庆华 沈永嘉 |
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| 作者单位： | 华东理工大学药学院制药工程系,上海,200237 |
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| 摘 要： | 2-乙酰噻吩经Mannich反应、还原、拆分、O-芳基化、N-脱甲基化及成盐反应等反应制得盐酸度洛西汀,总收率21%.
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| 关 键 词： | 盐酸度洛西汀 抗抑郁药 紧张性尿失禁 合成 |
| 文章编号： | 1001-8255（2006）06-0367-03 |
| 收稿时间： | 2005-11-08 |
| 修稿时间： | 2005-11-08 |
Synthesis of Duloxetine Hydrochloride |
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| YU Xin-Hong,WEN Xin-Min,TANG Jian,MAO Qing-Hua,SHEN Yong-Jia. Synthesis of Duloxetine Hydrochloride[J]. , 2006, 37(6): 367-369 |
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| Authors: | YU Xin-Hong WEN Xin-Min TANG Jian MAO Qing-Hua SHEN Yong-Jia |
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| Affiliation: | Dept. of Pharmaceutical Engneering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237 |
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| Abstract: | Duloxetine hydrochloride was synthesized from 2-acetylthiophene via Mannich reaction, reduction, resolution, O-arylation, N-demethylation and HCI salt formation in an overall yield of 21%. |
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| Keywords: | duloxetine hydrochloride antidepressant stress urinary incontinence synthesis |
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