红海榄叶的化学组成及其生物活性

红树植物是一类生长在热带和亚热带沿海潮间带并受周期性洁水浸淹的木本植物1].

Chemical constituents in the leave of Rhizophora stylosa L and their biological activities

Ten compounds were isolated from the leaves of Rhizophora stylosa, one kind of mangrove plants distributed in the tropical and subtropical areas of the world. Their structures were identified as taraxerone (1), taraxerol (2), β-sitosterol (3), careaborin (4), cis-careaborin (5), β-daucosterol (6), isovanillic acid (7), protocatechuic acid (8), astilbin (9) and rutin (10), among which compound 9 and 10 were reported in this plant for the first time. Of these compounds, compound 2 has been confirmed to have the abilities to inhibit the growth of Hela and BGC-823 with IC₅₀ of 73.4 μmol·L^-1 and 73.3 μmol·L^-1, respectively. Compound 5 could inhibit the growth of BGC-823 and MCF-7 with IC₅₀ of 45.9 μmol·L^-1 and 116.0 μmol·L^-1, respectively. Compound 9 and 10 were firstly reported to stimulate the proliferation of mice splenic lymphocytes markedly in a dose-dependent manner.