针刺对胚胎移植怀孕率的影响及其机理：随机安慰对照研究

目的:采用随机、安慰对照的研究方法,探讨在胚胎移植前后行针刺治疗在助孕技术中,如体外受精(IVF)或卵母细胞单精子注射(ICSI),对怀孕率的影响及其机理。方法:对210例接受IVF或ICSI的患者按完全随机的方法分成针刺治疗组、安慰针灸组和空白对照组,针刺治疗组在胚胎移植前后行体针针刺进行干预,安慰针灸组在胚胎移植前后用安慰针灸针进行干预,空白对照组未经过针灸治疗,观察3组子宫结合带的收缩频率及怀孕率。结果:胚胎移植前子宫结合带收缩频率3组间差异无显著性意义,胚胎移植后针刺治疗组则明显低于安慰针灸组和空白对照组,分别是2.8±1.4,4.3±1.8和4.1±1.9。针刺治疗组的70例中31例临床妊娠,怀孕率44.3％;安慰针灸组的70例中19例临床妊娠,怀孕率27.1％;空白对照组的70例中17例临床妊娠,怀孕率24.3％。治疗组的怀孕率显著高于安慰针灸组和空白对照组(P<0.05)。结论:提示针刺治疗在现代助孕技术中是改善怀孕率的有力工具。

Effect of acupuncture on the pregnancy rate in embryo transfer and mechanisms: A randomized and control study

Objective To observe the effect of acupuncture on the pregnancy rate in assisted reproduction therapy such as in-vitro-fertilisation (IVF) and intracytoplasmatic spermatozoen injection (ICSI), and mechanisms. Methods 210 cases undergoing IVF or ICSI were divided randomly into three groups: acupuncture treatment group, placebo group and control group. The acupuncture treatment group and the placebo group were treated respectively with body acupuncture and placebo acupuncture before and after embryo transfer, and in the control group embryos were transferred without any supportive therapy. Contraction frequency of the uterine junctional zone and the pregnancy rate were observed. Results The contraction frequency before embryo transfer was not significantly different among the three groups, but after embryo transfer in the acupuncture treatment group was lower than that in the placebo group and the control group, respectively. The pregnancy rate was 44.3% (31/70) inthe acupuncture treatment group, and 27.1% (19/70) in the placebo group and 24.3% (17/70) in the control group. The pregnancy rate in the acupuncture treatment group was significantly higher than that in the placebo acupuncture group and the control group (P<0.05). Conclusion Acupuncture is a powerful tool for improving pregnancy rate after assisted reproduction therapy.