新生儿急性细菌性结膜炎细菌培养结果分析

目的：分析新生儿急性细菌性结膜炎的细菌培养结果，探讨其病原菌和耐药性的变迁，寻找有效的抗生素，为临床合理用药提供依据。方法：对63例(97只眼)经临床诊断为新生儿急性细菌性结膜炎患儿的结膜囊分泌物标本进行细菌培养，同时对培养阳性菌株的种类及药物敏感试验结果进行分析。结果：新生儿急性细菌性结膜炎的细菌平均检出率为78．4％。不同年份的细菌检出率变化无明显差异(x^2＝0．79，P＞0．05)。新生儿急性细菌性结膜炎的致病菌，由以金黄色葡萄球菌、草绿色链球菌为主，转变为以淋球菌、表皮葡萄球菌和腐生葡萄球菌为主。大多数细菌对环丙沙星敏感，对氯霉素耐药。结论：对新生儿急性细菌性结膜炎患儿的结膜囊分泌物标本进行细菌培养、药物敏感试验既助于提高临床治疗，又可防止临床滥用抗生素、造成耐药菌株的增加。

An analysis of bacterial culture in acute neonatal conjunctivitis

Objective:To study the changes in positive rate of bacterial culture and drug sensitivity test of secretion specimens from the inferior palpebral conjunctival surface of neonate with acute bacterial conjunctivitis and to search for sensitive antibiotics. Methods:Secretion specimens were taken from 97 eyes of 67 cases of clinically diagnosed acute bacterial neonatal conjunctivitis for bacterial culture and drug sensitivity test. Results:Bacterial positive rate was 78 4% with no significant changes among the different ages.The main bacteria spectrum of acute neonatal conjunctivitis had changed from Staphylococcus aureus,Streptococcus viridans to Staphylococcus epidermidais,Staphylococcus saprophyticus and Neisseria gonorrhoeae.Ciprofloxacin was the most sensitive antibiotics.Most bacteria were resistant to Chloromycetin. Conclusions:The main bacteria spectrum of acute neonatal conjunctivitis had changed from Staphylococcus aureus,Streptococcus viridans to Staphylococcus epidermidais,Staphylococcus saprophyticus and Neisseria gonorrhoeae.Ciprofloxacin was the most sensitive antibiotics.Most bacteria were resistant to Chloromycetin.