特比萘芬软膏与复方酮康唑乳膏治疗浅部真菌病疗效比较

目的特比萘芬与复方酮康唑外用治疗皮肤浅部真菌病的疗效比较。方法浅部真菌病患者60例,随机分为特比萘芬组30例(应用特比萘芬软膏外涂患处,Bid×2周)和复方酮康唑组30例(外用复方酮康唑乳膏,Bid×2周);在停药时及停药2周后观察疗效。结果治疗结束时,特比萘芬组总有效率为73%(22/30),明显高于复方酮康唑组为57%(17/30)(P<0.05);停药2周后,特比萘芬组总有效率为97%(29/30),明显高于复方酮康唑组为47%(14/30)(P<0.05)。治疗结束时,特比萘芬组真菌清除率为83%,明显高于复方酮康唑组为53%(P<0.05),停药2周后,特比萘芬组真菌清除率为97%,明显高于复方酮康唑组为37%(P<0.01)。2组均未见明显不良反应。结论特比萘芬治疗浅部真菌病疗效优于复方酮康唑。

Compare the Effect of Terbinafine on Dermatophytosis with Compound Ketoconazole Cream

Objective To compare the effects of terbinafine and compound ketoconazole cream on dermatophytosis.Methods Sixty patients with dermatophytosis were randomly divided into 2 groups.Thirty patients were treated with terbinafine ointment.Thirty patients were treated with compound ketoconazole cream.The effects were evaluated after the treatment.Results The total effective rates at the end of treatment were 73%(22/30) for terbinafine group and 57%(17/30) for compound ketoconazole group(P>0.05);and the total effective rates were 97%(29/30) for terbinafine group and 47%(14/30) for compound ketoconazole group(P<0.05) 2 weeks after treatment.Mycological clearance rates were 83% for terbinafine group and 53% for compound ketoeonazole group(P<0.05) at the end of treatment;and 97% for terbinafine group and 37%for compound ketoeonazole group(P<0.01) 2 weeks after treatment.There were no adverse reactions in both groups.Conclusions Topical terbinafine is better than compound ketoconazole cream in the treatment of dermatophytoses.