| O-糖苷键连接的N-乙酰葡萄糖胺修饰及其心血管保护作用的研究进展 |
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| 引用本文： | 郑康,景亮. O-糖苷键连接的N-乙酰葡萄糖胺修饰及其心血管保护作用的研究进展[J]. 国际麻醉学与复苏杂志, 2011, 32(3): 378-381. DOI: 10.3760/cma.j.issn.1673-4378.2011.06.032 |
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| 作者姓名： | 郑康 景亮 |
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| 作者单位： | 东南大学附属中大医院麻醉科,南京,210009 |
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| 摘 要： | 背景 蛋白O-糖苷键连接的N-乙酰葡萄糖胺(O-GlcNAc)修饰是一种广泛存在的、动态的转录后修饰方式,通过N-乙酰氨基葡萄糖转移酶(β-N-acetylglucosaminyhransferase,OGT)及N-乙酰氨基葡萄糖苷酶(O-GlcNAcase,OGA)将N-乙酰葡萄糖胺单糖添加或移除到蛋白质的丝/苏氨酸...
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| 关 键 词： | O-GlcNAc修饰 心血管保护 抗炎症反应 热休克蛋白 抑制细胞凋亡 |
Advance in O-GlcNAc modification and its cardiovascular protective effects |
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| ZHENG Kang,JING Liang. Advance in O-GlcNAc modification and its cardiovascular protective effects[J]. international journal of anesthesiology and resuscitation, 2011, 32(3): 378-381. DOI: 10.3760/cma.j.issn.1673-4378.2011.06.032 |
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| Authors: | ZHENG Kang JING Liang |
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| Abstract: | Background O-linked attachment of the monosaccharide-N -acetylglucosamine(O-GlcNAc) is a highly dynamic and ubiquitous posttranslational protein modification, plays a critical role in regulating numerous biological processes. O -GlcNAc transferase and O-GlcNAcase are responsible for the addition and removal of O-GlcNAc from serine/threonine residues, respectively. Objective To review the potential mechanisms of O -GlcNAc modification and the target protein. Content Main potential mechanisms of O-GlcNAc modification include antagonizing inflammatory, increasing synthesis of HSPs, inhibiting apoptosis, etc. Trend Further insights into the signal pathway of O -GlcNAc modification may provide a nice prospect for the therapy of cardiovascular dysfunction. |
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| Keywords: | O-GlcNAc modification Cardiovascular protection Anti-inflammatory Heat shock proteins Anti-apoptosis |
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