| 肿瘤微环境中负性调节树突状细胞功能的因素及治疗策略 |
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| 引用本文： | 张晶,任秀宝. 肿瘤微环境中负性调节树突状细胞功能的因素及治疗策略[J]. 国际免疫学杂志, 2011, 34(4): 290-293. DOI: 10.3760/cma.j.issn.1673-4394.2011.04.013 |
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| 作者姓名： | 张晶 任秀宝 |
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| 作者单位： | 天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院生物治疗科,300060 |
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| 基金项目： | 天津市自然科学基金资助项目，天津市卫生局科技基金资助项目 |
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| 摘 要： | 在肿瘤免疫治疗中,树突状细胞(DCs)因拥有强大的抗原提呈功能而受到了极大的关注,但并非所有的DCs肿瘤疫苗都能够获得预期的效果.肿瘤微环境中及DCs自身存在的多种因素对DCs 抗原提呈功能的抑制是影响DCs肿瘤疫苗作用的一个重要原因.因此,认识并靶向性地降低或消除这些抑制性因素是增强Des肿瘤疫苗的一个重要研究方向.
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| 关 键 词： | 树突状细胞 肿瘤疫苗 治疗 |
The negative regulators toward dendritic cell in tumor microenvironment and corresponding therapy strategy |
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| ZHANG Jing,REN Xiu-bao. The negative regulators toward dendritic cell in tumor microenvironment and corresponding therapy strategy[J]. International Journal of Immunology, 2011, 34(4): 290-293. DOI: 10.3760/cma.j.issn.1673-4394.2011.04.013 |
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| Authors: | ZHANG Jing REN Xiu-bao |
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| Affiliation: | . Department of Cancer Biotherapy, Affiliated Tumor Hospital, Tiaafin Medical University;Key Laboratory of Cancer Prevention and Therapy of Tianfin, Tianfin 300060, China. |
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| Abstract: | In tumor biotherapy, DCs-based vaccines attract much more interests from investigators due to the superior antigen presentation capacity of DCs. However, not all DCs vaccines can meet the requirement of tumor treatment partly because of the negative regulators in tumor microenvironment or in DCs which adversely regulate the antigen presentation capacity of DCs. Thus, to decrease or to eliminate these negative regulators is a promising strategyfor the improvement of DCs vaccine. |
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| Keywords: | Dendritic cells Tumor vaccine Therapy |
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