孕妇血清一氧化氮水平与胎膜早破和绒毛膜羊膜炎的关系

目的 探讨血清NO水平与胎膜早破(PROM)及绒毛膜羊膜炎的关系.方法 将78例胎膜早破孕妇按照实际情况分为早产合并胎膜早破(pPROM)组33例和足月胎膜早破(tPROM)组45例,50例临产前剖宫产的胎膜完好孕妇为正常对照组,分析比较3组血清NO水平,观察3组发生绒毛膜羊膜炎的情况及绒毛膜羊膜炎患者血清NO水平.结果 pPROM组和tPROM组血清NO水平相近,均高于正常对照组,差异有统计学意义[(85±26)μmol/L、(83±21)μmoL/L比(60±16)μmoL/L,P＜0.05];pPROM组和tPROM组绒毛膜羊膜炎发生率高于正常对照组,差异有统计学意义[33.3%(11/33)、31.1%(14/45)比4.0%(2/50)];绒毛膜羊膜炎患者血清NO水平明显高于非绒毛膜羊膜炎患者,差异有统计学意义[(109±39)μmol/L比(73±33)μmol/L,P＜0.05].结论 血清NO水平的增高可能预示绒毛膜羊膜炎及胎膜早破的存在.

Abstract：

Objective To study the relationship between the level of nitric oxide(NO) in blood and premature rupture of membranes (PROM) and chorioamnionitis. Methods The 78 cases of premature rupture of membranes were divided into two groups according to the actual situation. The group of preterm premature rupture of membranes (pPROM) included 33 patients and the full-term premature rupture of membranes (tPROM) group had 45 patients. Fifty intact membranes' pregnant women who chose cesarean section before labor were selected as the normal control group. The levels of serum NO and the occurrence of chorioamnionitis were analyzed and compared among the three groups. Results The blood serum NO level was similar in PROM group and tPROM group but higher than that of the normal control group[(85 ±26)μmol/L, (83±21)μmol/L vs (60 ±16)μmol/L, P＜0.05]. The incidence of chorioamnionitis in PROM group and tPROM group was higher than that of the normal control group. The blood serum NO level of chorioamnionitis group was higher than that of the non-chorioamnionitis group [(109 ± 39)μmol/L vs (73 ± 33) μmol/L, P＜0. 05]. Couclusion The level of blood serum NO may predict PROM and chorioamnionitis.

Study on the relation between the level of nitric oxide in blood and premature rapture of membranes and chorioamnionitis

Objective To study the relationship between the level of nitric oxide(NO) in blood and premature rupture of membranes (PROM) and chorioamnionitis. Methods The 78 cases of premature rupture of membranes were divided into two groups according to the actual situation. The group of preterm premature rupture of membranes (pPROM) included 33 patients and the full-term premature rupture of membranes (tPROM) group had 45 patients. Fifty intact membranes' pregnant women who chose cesarean section before labor were selected as the normal control group. The levels of serum NO and the occurrence of chorioamnionitis were analyzed and compared among the three groups. Results The blood serum NO level was similar in PROM group and tPROM group but higher than that of the normal control group[(85 ±26)μmol/L, (83±21)μmol/L vs (60 ±16)μmol/L, P＜0.05]. The incidence of chorioamnionitis in PROM group and tPROM group was higher than that of the normal control group. The blood serum NO level of chorioamnionitis group was higher than that of the non-chorioamnionitis group [(109 ± 39)μmol/L vs (73 ± 33) μmol/L, P＜0. 05]. Couclusion The level of blood serum NO may predict PROM and chorioamnionitis.