钾离子浓度及离子通道电导对海马CA1区神经元自发放电的影响

目的 分析在胞外钾离子浓度[K+]0和离子通道电导变化的情况下,海马CA1区单个神经元自发放电频率和放电模式的变化.方法 对 Warman等提出的模型进行改进,应用计算机软件MATLAB建立一个包括16个房室的海马CA1区锥体细胞单个神经元的电缆模型.其中树突室不含有源通道,而胞体室含有5个离子通道(INa、INap、...

Effects of potassium concentration and ion channel conductance on spontaneous firing of Hippocampal CA1 neuron

Objective To analyse the variability of spontaneous firing frequencies and firing patterns of a Hippocampal CA1 neuron with the changes of extracellular potassium concentration[K+]0 and ion channel conductance.Methods A 16-compartment cable model of a Hippocampal CA1 neuron was developed based on the Warman model with computer software MATLAB.The dendrites contained no active channels,while five active channels (INa,INap,IDR,IA,IM)were contained in soma.In the model,the calcium currents and potassium currents(ICm,,ICT and IAHP) regulated by calcium concentration were not included.Results Simulation results showed that the neuron could generate periodicspontaneous firing activity.The spiking frequency increased with the increasing of[K+]0 and sodium conductance and decreasing of potassium conductance.Spontaneous single neuron activity appeared in singlet or in grouped bursts of two or three spikes.Conclusion The variability of spontaneous firing frequencies and firing patterns of single neuron are relevant to[K+]0 and ion channel conductance.