| 人乳头瘤病毒治疗性活载体疫苗的研究进展 |
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| 引用本文： | 吴小红,陈科达,吴洁,庄昉成. 人乳头瘤病毒治疗性活载体疫苗的研究进展[J]. 国际流行病学传染病学杂志, 2011, 38(3): 201-204. DOI: 10.3760/cma.j.issn.1673-4149.2011.03.018 |
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| 作者姓名： | 吴小红 陈科达 吴洁 庄昉成 |
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| 作者单位： | 浙江省医学科学院病毒病研究所,杭州,310013 |
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| 摘 要： | 高危型人乳头瘤病毒(HPV)-16和HPV-18在宫颈癌的致病过程中起着重要作用.近年来,HPV预防性疫苗已成功上市,但其费用较高,且不能治疗已感染的患者及相关的损伤.多种靶向E6/E7抗原的HPV治疗性疫苗已进入临床前模型和临床试验,包括活载体疫苗,多肽、蛋白疫苗,核酸疫苗及细胞疫苗.此文就HPV治疗性活载体疫苗进行...
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| 关 键 词： | 乳头状瘤病毒疫苗 载体 宫颈癌 |
Research progress of human papillonmavirus live vector-based vaccines |
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| WU Xiao-hong,CHEN Ke-da,WU Jie,ZHUANG Fang-cheng. Research progress of human papillonmavirus live vector-based vaccines[J]. International Journal of Epidemiology and Infectious Disease, 2011, 38(3): 201-204. DOI: 10.3760/cma.j.issn.1673-4149.2011.03.018 |
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| Authors: | WU Xiao-hong CHEN Ke-da WU Jie ZHUANG Fang-cheng |
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| Abstract: | The high-risk types of human papillomavirus (HPV-16 and HPV-18) play essential roles in the pathogenesis of cervical cancers. Despite recent advances in preventive HPV vaccine development, preventive HPV vaccines are costly and may not be capable of treating established HPV infections and HPV-associated esions. Various forms of therapeutic HPV vaccines targeting E6/E7 antigens have been tested in preclinical models and clinical trials, including live vector-based vaccines, peptide-based vaccines, protein-based vaccines, nucleic acid-based vaccines, and whole cellbased vaccines. Live-based therapeutic HPV vaccines are reviewed in the article. |
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| Keywords: | Papillomavirus vaccines Vectors Cervical cancer |
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