柴胡加龙骨牡蛎汤对脑卒中后抑郁患者血清脑源性神经营养因子及神经功能的影响

目的 探讨柴胡加龙骨牡蛎汤对脑卒中后抑郁(post-stroke depression,PSD)患者血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平及神经功能的影响.方法 将76例PSD患者按随机数字表法分为两组各38例,对照组采用常规疗法治疗,研究组在对照组治...

Effects of Chaihujia-Longgumuli decoction on serum levels of brain-derived neurotrophic factor in patients with post-stroke depression

Objective To investigate the effects of Chaihujia-Longgumuli decoction on brain-derived neurotrophic factor (BDNF) levels and neurological function in patients with post-stroke depression (PSD). Methods Patients meet the diagnostic criteria of the PSD were randomly recurited into a control group and a study group.The control group received conventional therapy. On this basis, the study group was treated with Chaihujia-Longgumuli decoction.The levels of serum BDNF,Hamilton Depression Scale(HAMD-24), neurological impairment rating scale (MESSS), stroke rehabilitation assessment of movement table (STREAM) rate situation and clinical efficacy were compared between the two groups. Results After treated for 3 weeks and 6 weeks,the serum BDNF level in the study group was significantly higher(t=2.52、 2.14. P＜0.05) than the control group, while HAMD score was significantly lower than the control group(t=2.07、3.02,P＜0.01). MESSS score in the study group was also significantly lower than control group (t=2.51、4.50, P＜0.01). After 6 weeks treatment both STREAM score(t=2.01, P＜0.05) and the therapeutic effects (x2=7.93,P＜0.05) showed significant difference between the two groups. Conclusion Chaihujia-Longgumuli decoction can increase serum BDNF levels, reduce depression, improve nerve and motor function and boost clinical efficacy.