| MMP-2、MMP-9及其抑制剂TIMP-2、TIMP-1与肾脏疾病 |
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| 引用本文： | 童桂霞,胡晓晶. MMP-2、MMP-9及其抑制剂TIMP-2、TIMP-1与肾脏疾病[J]. 国际儿科学杂志, 2011, 38(4): 416-419. DOI: 10.3760/cma.j.issn.1673-4408.2011.04.033 |
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| 作者姓名： | 童桂霞 胡晓晶 |
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| 作者单位： | 1. 山东大学第二医院儿内科,济南,250033
2. 青岛市立医院儿内科,266000 |
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| 摘 要： | 肾脏细胞外基质(ECM)合成与降解失衡及其组织重塑导致的ECM积聚,是各种肾脏疾病发展至肾间质纤维化与肾小球硬化乃至终末期肾衰的共同病理表现.基质金属蛋白酶(MMP)是肾脏ECM降解的关键酶,金属蛋白酶组织抑制因子(TIMP)-2、-1分别为MMP-2、MMP-9内源性抑制剂.在不同类型的肾脏疾病或同一疾病的不同病理发...
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| 关 键 词： | 基质金属蛋白酶 金属蛋白酶组织抑制因子 肾脏 |
Matrix metalloproteinase-2(MMP-2)and MMP-9 or tissue inhibitors of metalloproteinase-2( TIMP-2) and TIMP-1 and kidney diseases |
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| TONG Gui-xia,HU Xiao-jing. Matrix metalloproteinase-2(MMP-2)and MMP-9 or tissue inhibitors of metalloproteinase-2( TIMP-2) and TIMP-1 and kidney diseases[J]. International Journal of Pediatrics, 2011, 38(4): 416-419. DOI: 10.3760/cma.j.issn.1673-4408.2011.04.033 |
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| Authors: | TONG Gui-xia HU Xiao-jing |
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| Abstract: | Alterations in the balance between synthesis and degradation of extracellular matrix( ECM) and its remodeling may result in an accumulation of ECM molecules and lead to tubulointerstitial fibrosis and glomerulosclerosis and end-stage renal failure. The major physiologic regulators of ECM degradation in the glomerulus are matrix metalloproteinases ( MMP). Tissue inhibitors of metalloproteinase-2 and-1 (TIMP-2 and TIMP-1)are endogenous inhibitors of MMP-2 and MMP-9 respectively. The expression or activity of MMP and TIMP is different in all kinds of kidney diseases or pathophysiological processes. This article reviews the interrelationship of MMP-2, MMP-9, TIMP-1, TIMP-2 and kidney diseases. |
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| Keywords: | Matrix metalloproteinases Tissue inhibitors of metalloproteinase Kidney |
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