急性心肌梗死发病清晨高峰现象的影响因素分析

目的 探讨急性心肌梗死(AMI)发病清晨高峰现象的影响因素.方法 连续入选2002年10月到2006年9月北京大学人民医院发病时间明确的AMI患者,共874例.统计AMI发病时间的昼夜节律,找出AMI发病的清晨高峰,用多元非条件Logistic回归分析探寻AMI发病清晨高峰的影响因素.结果 AMI的发病时间有明显的昼夜节律,高峰在6:01～9:00时(146例,16.7%,与其他时间段比较,P＜0.05).多元非条件Logistic回归分析显示,男性(OR=1.74,95%CI:1.11～2.73,P＜0.05)、高血压病史(OR=1.71,95%CI:1.17～2.51,P＜0.01)和梗死前心绞痛(OR=1.61,95%CI:1.08～2.38,P＜0.05)是AMI发病清晨高峰的独立危险因素.结论 AMI的发病时间有明显的清晨高峰现象,男性、高血压病史和梗死前心绞痛是AMI发病清晨高峰的独立危险因素.

Abstract：

Objective To investigate the morning peak of onset time in patients with acute myocardial infarction(AMI) and its risk factors. Methods A retrospective analysis of patients(n = 874) diagnosed with AMI between October 2002 and September 2006 in Peking University people's hospital was carried out. We calculated the number and the percentage of AMI cases and found out the morning peak time of AMI's onset. The clinical factors in relation to the peak time of AMI's onset were analyzed using multivariate unconditional Logistic regression. Results There was a circadian rhythm of AMI with a peak incidence during 6:01-9:00 (P＜0. 05, compared with other times). Logistic regression analysis showed that the risk factors of the morning peak of AMI's onset included men (0R= 1.74, 95% CI: 1.11-2.73, P＜0.05), the history of hypertension (OR =1.71, 95% CI:1. 17-2.51, P＜ 0.01) and the preinfarction angina(OR = 1.61, 95%CI:1.08-2. 38, P＜0.05). Conclusions AMI is more likely to happen in the morning hours. Men, hypertension and the preinfarction angina are the independent risk factors associated with AMI's onset.

The morning peak of acute myocardial infarction' s onset and its risk factors

Objective To investigate the morning peak of onset time in patients with acute myocardial infarction(AMI) and its risk factors. Methods A retrospective analysis of patients(n = 874) diagnosed with AMI between October 2002 and September 2006 in Peking University people's hospital was carried out. We calculated the number and the percentage of AMI cases and found out the morning peak time of AMI's onset. The clinical factors in relation to the peak time of AMI's onset were analyzed using multivariate unconditional Logistic regression. Results There was a circadian rhythm of AMI with a peak incidence during 6:01-9:00 (P＜0. 05, compared with other times). Logistic regression analysis showed that the risk factors of the morning peak of AMI's onset included men (0R= 1.74, 95% CI: 1.11-2.73, P＜0.05), the history of hypertension (OR =1.71, 95% CI:1. 17-2.51, P＜ 0.01) and the preinfarction angina(OR = 1.61, 95%CI:1.08-2. 38, P＜0.05). Conclusions AMI is more likely to happen in the morning hours. Men, hypertension and the preinfarction angina are the independent risk factors associated with AMI's onset.