| 天然产物与药物发现研究评述 |
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| 引用本文： | 李飞,杨宝学. 天然产物与药物发现研究评述[J]. 国际中医中药杂志, 2011, 33(7). DOI: 10.3760/cma.j.issn.1673-4246.2011.07.011 |
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| 作者姓名： | 李飞 杨宝学 |
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| 作者单位： | 1. 北京大学基础医学院,100191
2. 北京大学基础医学院药理学系膜通道药理学研究室,100191 |
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| 基金项目： | 国家自然科学基金，国家985计划，"重大新药创制"科技重大专项子项目 |
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| 摘 要： | 天然产物是药物发现与筛选的物质基础,高效、快速的药物筛选技术是获得天然产物线索化合物的重要前提.本文从药物研发环境、药物研发面临的困难、现代化的药物筛选技术、获得类似物的方法等方面综述了天然产物药物发现与药物筛选的现状及开发前景.Abstract：Natural products were the material basis of drug discovery and drug screening, and high-performance techniques were the important prerequisite of earning hits. In this paper, we reviewed the current situation and future prospects of drug screening, including the pharmaceutical environment, the challenges facing drug discovery, the screening tools and the methods of generating analogs.
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| 关 键 词： | 天然产物 药物发现 药物筛选 |
The research profile of natural products and drug discovery |
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| LI Fei,YANG Bao-xue. The research profile of natural products and drug discovery[J]. International Journal of Traditional Chinese Medicine, 2011, 33(7). DOI: 10.3760/cma.j.issn.1673-4246.2011.07.011 |
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| Authors: | LI Fei YANG Bao-xue |
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| Abstract: | Natural products were the material basis of drug discovery and drug screening, and high-performance techniques were the important prerequisite of earning hits. In this paper, we reviewed the current situation and future prospects of drug screening, including the pharmaceutical environment, the challenges facing drug discovery, the screening tools and the methods of generating analogs. |
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| Keywords: | Natural products Drug discovery Drug screening |
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