| 家族性甲状腺髓样癌的基因相关性研究 |
| |
| 引用本文： | 陈宇,李娟. 家族性甲状腺髓样癌的基因相关性研究[J]. 国际遗传学杂志, 2011, 34(3). DOI: 10.3760/cma.j.issn.1673-4386.2011.03.009 |
| |
| 作者姓名： | 陈宇 李娟 |
| |
| 作者单位： | 宁厦医科大学附属医院核医学科,银川,750004 |
| |
| 摘 要： | 甲状腺髓样癌(medullary thyroid carcinoma,MTC)的发病率约占甲状腺癌发病率的5%～10%,而家族性甲状腺髓样癌(familial medullary thyriod carcinoma,FMTC)的发病率约占甲状腺髓样癌发病率的20%左右,且发病率有不断增高的趋势.目前公认RET原癌基因(编码受体酪氨酸激酶)是导致FMTC的主要原因.PET基因仅通过点突变即可以导致甲状腺癌的发生.该文对RET原癌基因的正常功能以及与FMTC的相关性研究作一综述.Abstract：About 5%～10% of thyroid carcinoma is medullary thyroid carcinoma(MTC),of which,about 20% are familial medullary thyriod carcinoma(FTMC).There is a trend that the incidence has been noticed to increase.Currently it has been known that RET proto-oncogene(encoding receptor tyrosine kinase)is only gene involved in the pathogenesis of FTMC.In this particle,We will view the function of PET proto-oncogene and its association with FTMC.
|
| 关 键 词： | PET原癌基因 遗传性甲状腺髓样癌 突变 |
Review of gene relevance research of familial medullary thyriod carcinoma |
| |
| CHEN Yu,LI Juan. Review of gene relevance research of familial medullary thyriod carcinoma[J]. International JOurnal of Genetics, 2011, 34(3). DOI: 10.3760/cma.j.issn.1673-4386.2011.03.009 |
| |
| Authors: | CHEN Yu LI Juan |
| |
| Abstract: | About 5%～10% of thyroid carcinoma is medullary thyroid carcinoma(MTC),of which,about 20% are familial medullary thyriod carcinoma(FTMC).There is a trend that the incidence has been noticed to increase.Currently it has been known that RET proto-oncogene(encoding receptor tyrosine kinase)is only gene involved in the pathogenesis of FTMC.In this particle,We will view the function of PET proto-oncogene and its association with FTMC. |
| |
| Keywords: | PET proto-oncogene Familial medullary carcinoma Mutation |
| 本文献已被 万方数据 等数据库收录！ |
|
