| 川崎病患儿血浆中N末端脑利钠肽原升高机制的研究进展 |
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| 引用本文： | 王恋,沈雁文. 川崎病患儿血浆中N末端脑利钠肽原升高机制的研究进展[J]. 国际儿科学杂志, 2011, 38(4): 350-352. DOI: 10.3760/cma.j.issn.1673-4408.2011.04.013 |
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| 作者姓名： | 王恋 沈雁文 |
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| 作者单位： | 中国医科大学,沈阳,110001 |
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| 摘 要： | 川崎病是以全身血管炎为主要病变的急性发热出疹性疾病,其诊断主要依靠临床表现是否符合诊断标准及排除类似疾病,缺乏特异性的诊断手段.近年来,血浆脑利钠肽(BNP)在诊断川崎病中的价值逐渐被人们所重视.研究发现川崎病患儿血浆N末端脑利钠肽原(NT-proBNP)水平在急性期显著升高,具有一定的特异性和敏感性,其升高原因可能与...
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| 关 键 词： | 皮肤黏膜淋巴结综合征 肽碎片 利钠肽 |
Progress in the mechanism of plasma N-terminal pro-brain natriuretic peptide in children with Kawasaki disease |
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| WANG Lian,SHEN Yan-wen. Progress in the mechanism of plasma N-terminal pro-brain natriuretic peptide in children with Kawasaki disease[J]. International Journal of Pediatrics, 2011, 38(4): 350-352. DOI: 10.3760/cma.j.issn.1673-4408.2011.04.013 |
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| Authors: | WANG Lian SHEN Yan-wen |
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| Abstract: | Kawasaki disease ( KD) is an acute febrile systemic vasculitic syndrome. Since there is no specific diagnostic test for KD, the diagnosis is mainly based on the clinical menifetations according to the criterias and excluding of other diseases. Recently the value of plasma brain natriuretic peptide ( BNP) in the diagnosis of KD has been paid more attention gradually. The plasma NT-proBNP level is significantly elevated in KD patients in the acute phase. It is of some specificity and sensitivity, and it may due to the local myocardial inflammation, cytokines and diastolic function of left ventricular. This review summarizes the mechanisms by which the elevated levels of plasma NT-proBNP occur in the acute phase of KD. |
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| Keywords: | Mucocutaneous lymph node syndrome Peptide fragments Natriuretie peptide |
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