麻醉药物后处理心肌的胞内信号转导研究进展

背景 麻醉药物后处理是最近提出的一种心肌保护的新策略,具有很好的临床应用前景.目的 麻醉药物后处理对心肌再灌注损伤的保护是多因素参与的复杂过程,对麻醉药物后处理中心肌胞内信号转导的作用机制及研究进展作一综述.内容 麻醉药物后处理除了通过减少活性氧类物质的产生、抑制线粒体内钙超载、减轻内皮功能失调等被动作用外,还可主动激...

Progress of signal transduction in myocardial anesthetic postconditioning

Background Anesthetic postconditioning which is a novel cardioprotective strategy can attenuate myocardial reperfusion injury. Objective The article will review the signaling pathway in myocardium during anesthetic postconditioning. Content Besides the reduction in generation of reactive oxygen species, calcium overload and endothelial dysfunction, anesthetic postconditioning can also activate the pro-survival signaling pathways such as the extracellular signal-regulated kinase(ERK) and the phosphoinositide -3 -kinase/Akt (PI3K/Akt) pathways. These pathways might play an important role in the protective effects of anesthetic postconditioning, which stimulated the endogenous anti -injury capacity of cells to protect themselves. Trend Endogenous mechanisms evoked by anesthetic postconditioning provide a new direction of research on mechanisms of cardioprotection and the theoretical support for cardioprotective effects of anesthetic.