瞬时感受器电位香草酸受体1与疼痛治疗

背景 疼痛是临床上常见却又难以达到满意治疗效果的综合征.以往的镇痛药物主要致力于阻断疼痛刺激向大 脑传递,而非针对疼痛产生的根源,即介导疼痛的受体.目前随着疼痛刺激性受体的识别与克隆,疼痛治疗领域得以新的发展.目的 总结近期国内外对瞬时感受器电位香草酸受体1(transient receptor potential v...

Transient receptor potential vanilloid 1 and pain management

Background It is difficult to satisfactorily cure pain. Current analgesic drugs focused on preventing the transmission of action potentials from reaching the brain rather than pinpointing the springhead giving birth to pain, the receptor itself. Due to the clone of the pain receptors, pain management have taken a step forward. Objective To summarize the recent research on the agonists and antagonists of Transient Receptor Potential vanilloid 1 (TRPV1) at home and abroad to explore new field of pain management. Content TRPV1 is a nonselective cation channel. Compelling data has been gathered on the role of the channel in inflammatory and neuropathic diseases. The agonist and antagonist of TRPV1 interrupt the generation and transmission to achieve the purpose of analgesia. Trend The agonist and antagonist of TRPV1 with high efficiency but less side effects will be research hot topics in pain treatment.