炎症反应在心肌缺血/再灌注损伤中作用的研究进展

背景 心肌缺血/再灌注损伤(ischemia/reperfusion injury,I/RI)是指在缺血心肌恢复血流灌注后,细胞代谢功能障碍和结构破坏反而加重的现象,并且伴随有以炎症细胞浸润和细胞因子产生为特征的炎症反应.目前认为,炎症反应是I/RI的重要病理机制之一,再灌注诱发的炎症反应及其介质可加重心肌I/RI,而...

The role of inflammatory response in myocardial ischemia reperfusion injury

Background Myocardial/ischemia reperfusion injury (I/RI) is defined as myocardial injury caused by the restoration of coronary blood flow after an ischemic episode, which leads to severe myocyte metabolic derangements and ultrastructural impairment. The I/RI also triggers the activation of an inflammatory cascade evidenced by neutrophils accumulating and inflammatory mediators releasing. Thus the inflammatory response has been recognized as one of the most important mechanisms of I/ RI. It has been identified that reperfusion -induced inflammation and excessive production of cytokines can promote myocardial damage during ischemia and reperfusion. Thus modulating the inflammatory response at the onset of reperfusion may represent a potent therapeutic strategy to attenuate the myocardial I/RI. Objective Objects of this review are to evaluate the possible roles of the inflammatory response in mechanisms of myocardial I/RI. Content The effects of inflammatory mediators including inflammatory cells and cytokines in I/RI process are in detailed introduced. Trend The inflammatory response is exactly an important mechanism in IRI, but its effects in the I/RI process are not simple. Except damages caused by the inflammatory response, it can produce benefits. For improving cardioprotection, all treatments by regulating I/RI -induced inflammation should keep the balance of its two sides.