| 日本脑炎病毒蛋白与宿主蛋白的相互作用 |
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| 引用本文： | 丁德平,冯国和. 日本脑炎病毒蛋白与宿主蛋白的相互作用[J]. 国际流行病学传染病学杂志, 2011, 38(3): 208-211. DOI: 10.3760/cma.j.issn.1673-4149.2011.03.020 |
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| 作者姓名： | 丁德平 冯国和 |
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| 作者单位： | 中国医科大学附属盛京医院感染科,沈阳,110004 |
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| 摘 要： | 日本脑炎病毒(JEV)隶属于黄病毒科黄病毒属,所致的日本脑炎为经蚊虫传播的人畜共患疾病,主要累及中枢神经系统,病死率高,因其致病机制复杂,至今尚无特异治疗方法.近年研究表明,JEV蛋白与宿主细胞蛋白的相互作用对病毒复制、嗜神经毒力、神经细胞增殖/凋亡、IFN抵抗及诱导宿主保护性免疫等方面可产生重要影响.此文重点从JEV...
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| 关 键 词： | 脑炎病毒亚组,日本 病毒蛋白 细胞凋亡 |
Interaction between Japanese encephalitis virus proteins and host proteins |
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| DING De-ping,FENG Guo-he. Interaction between Japanese encephalitis virus proteins and host proteins[J]. International Journal of Epidemiology and Infectious Disease, 2011, 38(3): 208-211. DOI: 10.3760/cma.j.issn.1673-4149.2011.03.020 |
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| Authors: | DING De-ping FENG Guo-he |
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| Abstract: | Japanese encephalitis virus(JEV) belongs to flaviviridae family, it can causes Japanese encephalitis which is mosquito-borne zoonotic diseases. The disease mainly referes to central nervous system with high mortality. Because its pathogenesis has not been fully defined, there is no specific treatment for it. Recent researches suggest that the interaction between JEV proteins and host proteins has very important influence on the virus replication, neurovirulence, neuronal proliferation/apoptosis, interferon resistance and induces protective immunity. The progress in molecular mechanisms for the interaction between JEV proteins and host proteins from the aspects of JEV genomic structure, structure proteins, nonstructural proteins and their function are described in the article. |
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| Keywords: | Encephalitis virus,Japanese Virus proteins Apoptosis |
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